Gas chromatographic and mass spectrometric studies on the metabolism and pharmacokinetics of Δ 1-tetrahydrocannabinol in the rabbit
Gas chromatography-mass spectrometry has been used to investigate the in vivo hepatic metabolism of Δ 1-tetrahydrocannabinol (Δ 1-THC) in the New Zealand white rabbit. Sixteen metabolites were identified and shown to be present in different relative amounts compared with the hepatic metabolites of Δ...
Saved in:
| Published in: | Journal of Chromatography A 1982-01, Vol.239, p.243-250 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | eng |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Gas chromatography-mass spectrometry has been used to investigate the
in vivo hepatic metabolism of Δ
1-tetrahydrocannabinol (Δ
1-THC) in the New Zealand white rabbit. Sixteen metabolites were identified and shown to be present in different relative amounts compared with the hepatic metabolites of Δ
1-THC produced by other species. The metabolic profile was also different from that reported from rabbit urine particularly with regard to the lower relative concentrations of acidic metabolites in the liver. The pharmacokinetics of Δ
1-THC has been studied in the rabbit using the recently developed GC-MS method based on metastable ion monitoring. This revealed a terminal plasma Δ
1-THC half life ranging from 34.16 to 59.30 h (mean 46.75 h) after a single dose and a THC fat/plasma ratio of 10
3–10
4:1. |
|---|---|
| ISSN: | 0021-9673 |