Risk Factors and Outcome of Infections by Multidrug-Resistant Gram-Negative Bacteria in Patients Undergoing Hematopoietic Stem Cell Transplantation

Highlights • We reported the results of a 3-year surveillance program of infections by multidrug resistant Gram- negative (MDR GN) bacteria in a Transplant Unit. • Cumulative incidence of MDR GN infections was 10,5%. • Allogeneic transplant and colonization by MDR GN bacteria at admission to the Tra...

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Bibliographic Details
Published in:Biology of blood and marrow transplantation 2016
Main Authors: Patriarca, F, Cigana, C, Massimo, D, Lazzarotto, D, Geromin, A, Isola, M, Battista, ML, Medeot, M, Cerno, M, Sperotto, A, Candoni, A, Crapis, M, Sartor, A, Scarparo, C, Bassetti, M, Fanin, R
Format: Article
Language:English
Subjects:
Hematology, Oncology and Palliative Medicine
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Summary:Highlights • We reported the results of a 3-year surveillance program of infections by multidrug resistant Gram- negative (MDR GN) bacteria in a Transplant Unit. • Cumulative incidence of MDR GN infections was 10,5%. • Allogeneic transplant and colonization by MDR GN bacteria at admission to the Transplant Unit were significantly associated with an increased risk of infection. • Patients who proceeded to allogeneic transplant and developed MDR GN infections had a significantly higher TRM and a poorer OS, in comparison with patients without MDR infections. • The risk-benefit ratio of performing an allogeneic transplant could be carefully evaluated in patients colonized with MDR GN bacteria.
ISSN:1083-8791
1523-6536
DOI:10.1016/j.bbmt.2016.11.005