Molecular finds of pressure ulcer: A bioinformatics approach bioinformatics approach in pressure ulcer

Abstract Background Understanding the biological processes underlying Pressure Ulcer (PU) is an important strategy to identify new molecular targets. Bioinformatics has emerged as an important screening tool for a broad range of diseases. Objective This study aim of the current study is to investiga...

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Bibliographic Details
Published in:Journal of tissue viability 2017
Main Authors: Santos, Eloa Mangabeira, Farias, Lucyana Conceição, Santos, Sérgio Henrique Sousa, de Paula, Alfredo Maurício Batista, de Oliveira e Silva, Carla Silvana, Guimarães, André Luiz Sena
Format: Article
Language:English
Subjects:
Advanced Basic Science
Critical Care
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Summary:Abstract Background Understanding the biological processes underlying Pressure Ulcer (PU) is an important strategy to identify new molecular targets. Bioinformatics has emerged as an important screening tool for a broad range of diseases. Objective This study aim of the current study is to investigate the protein-protein interaction in the PU context by bioinformatics. Methods We performed a search in gene databases, and bioinformatics algorithms were used to generate molecular targets for PU based in silico investigation. Interactions networks between protein-coding genes were built and compared to skin. Results TNFA, MMP9, and IL10 genes have higher disease-related connectivity than a connectivity general global. MAGOH , UBC , and PTCH1 as were leader genes related to skin. Ontological analysis demonstrated different mechanisms associated, such as response to oxidase stress. Conclusion TNFA, MMP9, and IL10 are possible therapeutic targets for pressure ulcer. Additional investigation of cell post-transcriptional machinery should be investigated in PU.
ISSN:0965-206X
DOI:10.1016/j.jtv.2017.01.002