Raw means (and SDs) of sAA and cortisol for (a) Waking sample, (b) daily output (AUCi), and (c) sleep scores, across the three interventions

Summary Objective The main aim of this exploratory study was to assess whether salivary α-amylase (sAA) and salivary cortisol levels would be positively modulated by sleep-focused mind–body interventions in female and male cancer survivors. Methods We conducted a randomized controlled trial in which...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2013, Vol.38 (9), p.1521-1531
Main Authors: Lipschitz, David L, Kuhn, Renee, Kinney, Anita Y, Donaldson, Gary W, Nakamura, Yoshio
Format: Article
Language:English
Subjects:
Endocrinology & Metabolism
Psychiatry
Online Access:Get full text
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Summary:Summary Objective The main aim of this exploratory study was to assess whether salivary α-amylase (sAA) and salivary cortisol levels would be positively modulated by sleep-focused mind–body interventions in female and male cancer survivors. Methods We conducted a randomized controlled trial in which 57 cancer survivors with self-reported sleep disturbance received either a Sleep Hygiene Education (SHE; n = 18) control, or one of two experimental mind–body interventions, namely, Mind–Body Bridging (MBB; n = 19) or Mindfulness Meditation (MM; n = 20). Interventions were three sessions each conducted once per week for three consecutive weeks. Saliva cortisol and sAA were measured at baseline and 1 week after the last session. Participants also completed a sleep scale at the same time points when saliva was collected for biomarker measurement. Results Our study revealed that at post-intervention assessment, mean sAA levels upon awakening (“Waking” sample) declined in MBB compared with that of SHE. Mean Waking cortisol levels did not differ among treatment groups but declined slightly in SHE. Self-reported sleep improved across the three interventions at Post-assessment, with largest improvements in the MBB intervention. Conclusion In this exploratory study, sleep focused mind–body intervention (MBB) attenuated Waking sAA levels, suggesting positive influences of a mind–body intervention on sympathetic activity in cancer survivors with sleep disturbance.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2012.12.021