Original article: Varicella vaccination elicits a humoral and cellular response in children with rheumatic diseases using immune suppressive treatment

Highlights • Children with rheumatic diseases had similar humoral responses to controls after VZV-vaccination. • Type of immunosuppressive drug did not affect the humoral immune response significantly. • After vaccination, VZV-specific T-cell responses had increased in patients. • Reported adverse e...

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Bibliographic Details
Published in:Vaccine 2017
Main Authors: Groot, Noortje, Pileggi, Gecilmara, Sandoval, Cleonice B, Grein, Ingrid, Berbers, Guy, Ferriani, Virginia Paes Leme, Wulffraat, Nico, de Roock, Sytze
Format: Article
Language:English
Subjects:
Allergy and Immunology
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Summary:Highlights • Children with rheumatic diseases had similar humoral responses to controls after VZV-vaccination. • Type of immunosuppressive drug did not affect the humoral immune response significantly. • After vaccination, VZV-specific T-cell responses had increased in patients. • Reported adverse events were mild and limited to three of 49 patients and one of 18 controls. • Three of 49 patients received biologicals. They did not respond adequately to VZV-vaccination.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2017.04.015