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Fluorescence and Diffuse Reflectance Spectroscopy for Breast Cancer Diagnosis During Core Needle Biopsy
The goal of this project is to explore the potential of using tissue fluorescence and diffuse reflectance spectroscopy for breast cancer detection during a core needle breast biopsy. Both empirically based and model based approaches have been explored for the extraction of diagnostically useful info...
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creator | Zhu, Changfang |
description | The goal of this project is to explore the potential of using tissue fluorescence and diffuse reflectance spectroscopy for breast cancer detection during a core needle breast biopsy. Both empirically based and model based approaches have been explored for the extraction of diagnostically useful information from the tissue spectra, as well as the diagnosis of breast cancer based on these extracted features. For the sample set investigated in our study, both intrinsic tissue properties extracted using model based approach and spectral features extracted using empirical spectral analysis could provide sensitivity and specificity of up to 89% for discriminating breast malignancy. These outcomes provided the foundation for using the optical sensor based on tissue fluorescence and diffuse reflectance spectroscopy as an adjunct diagnostic tool, which has the potential to provide guidance for core needle breast biopsy. |
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Both empirically based and model based approaches have been explored for the extraction of diagnostically useful information from the tissue spectra, as well as the diagnosis of breast cancer based on these extracted features. For the sample set investigated in our study, both intrinsic tissue properties extracted using model based approach and spectral features extracted using empirical spectral analysis could provide sensitivity and specificity of up to 89% for discriminating breast malignancy. These outcomes provided the foundation for using the optical sensor based on tissue fluorescence and diffuse reflectance spectroscopy as an adjunct diagnostic tool, which has the potential to provide guidance for core needle breast biopsy.</description><language>eng</language><subject>Atomic and Molecular Physics and Spectroscopy ; BIOPSY ; BREAST CANCER ; CORES ; DETECTION ; DIAGNOSIS(MEDICINE) ; DIAGNOSTIC EQUIPMENT ; DIFFUSE REFLECTANCE ; DIFFUSE REFLECTION ; DISCRIMINATION ; EXPERIMENTAL DATA ; EXTRACTION ; FLUORESCENCE ; MAMMARY GLANDS ; Medicine and Medical Research ; NEEDLES ; OPTICAL DETECTORS ; Optics ; SPECTRA ; SPECTROSCOPY ; SPECTRUM ANALYSIS</subject><creationdate>2007</creationdate><rights>Approved for public release; distribution is unlimited.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,786,891,27600,27601</link.rule.ids><linktorsrc>$$Uhttps://apps.dtic.mil/sti/citations/ADA477034$$EView_record_in_DTIC$$FView_record_in_$$GDTIC$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Zhu, Changfang</creatorcontrib><creatorcontrib>WISCONSIN UNIV-MADISON</creatorcontrib><title>Fluorescence and Diffuse Reflectance Spectroscopy for Breast Cancer Diagnosis During Core Needle Biopsy</title><description>The goal of this project is to explore the potential of using tissue fluorescence and diffuse reflectance spectroscopy for breast cancer detection during a core needle breast biopsy. Both empirically based and model based approaches have been explored for the extraction of diagnostically useful information from the tissue spectra, as well as the diagnosis of breast cancer based on these extracted features. For the sample set investigated in our study, both intrinsic tissue properties extracted using model based approach and spectral features extracted using empirical spectral analysis could provide sensitivity and specificity of up to 89% for discriminating breast malignancy. These outcomes provided the foundation for using the optical sensor based on tissue fluorescence and diffuse reflectance spectroscopy as an adjunct diagnostic tool, which has the potential to provide guidance for core needle breast biopsy.</description><subject>Atomic and Molecular Physics and Spectroscopy</subject><subject>BIOPSY</subject><subject>BREAST CANCER</subject><subject>CORES</subject><subject>DETECTION</subject><subject>DIAGNOSIS(MEDICINE)</subject><subject>DIAGNOSTIC EQUIPMENT</subject><subject>DIFFUSE REFLECTANCE</subject><subject>DIFFUSE REFLECTION</subject><subject>DISCRIMINATION</subject><subject>EXPERIMENTAL DATA</subject><subject>EXTRACTION</subject><subject>FLUORESCENCE</subject><subject>MAMMARY GLANDS</subject><subject>Medicine and Medical Research</subject><subject>NEEDLES</subject><subject>OPTICAL DETECTORS</subject><subject>Optics</subject><subject>SPECTRA</subject><subject>SPECTROSCOPY</subject><subject>SPECTRUM ANALYSIS</subject><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>2007</creationdate><recordtype>report</recordtype><sourceid>1RU</sourceid><recordid>eNqFjLEKwyAURV06lLZ_0OH9QKGQQOZEEzp1aLsH0acIouLTIX9fA9073cM93HtkdvE1ZiSFQSHIoEE4YyohvNB4VEXu_Ts1ypFUTBuYmGHKKKkA321uE2lDJEcganbBAm-X8ETUHmFyMdF2ZgcjPeHllyd2XeYPf9x0cWql4gKWdRRjPwz3ru_-6C8DmjyH</recordid><startdate>200709</startdate><enddate>200709</enddate><creator>Zhu, Changfang</creator><scope>1RU</scope><scope>BHM</scope></search><sort><creationdate>200709</creationdate><title>Fluorescence and Diffuse Reflectance Spectroscopy for Breast Cancer Diagnosis During Core Needle Biopsy</title><author>Zhu, Changfang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-dtic_stinet_ADA4770343</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Atomic and Molecular Physics and Spectroscopy</topic><topic>BIOPSY</topic><topic>BREAST CANCER</topic><topic>CORES</topic><topic>DETECTION</topic><topic>DIAGNOSIS(MEDICINE)</topic><topic>DIAGNOSTIC EQUIPMENT</topic><topic>DIFFUSE REFLECTANCE</topic><topic>DIFFUSE REFLECTION</topic><topic>DISCRIMINATION</topic><topic>EXPERIMENTAL DATA</topic><topic>EXTRACTION</topic><topic>FLUORESCENCE</topic><topic>MAMMARY GLANDS</topic><topic>Medicine and Medical Research</topic><topic>NEEDLES</topic><topic>OPTICAL DETECTORS</topic><topic>Optics</topic><topic>SPECTRA</topic><topic>SPECTROSCOPY</topic><topic>SPECTRUM ANALYSIS</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Changfang</creatorcontrib><creatorcontrib>WISCONSIN UNIV-MADISON</creatorcontrib><collection>DTIC Technical Reports</collection><collection>DTIC STINET</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Zhu, Changfang</au><aucorp>WISCONSIN UNIV-MADISON</aucorp><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><btitle>Fluorescence and Diffuse Reflectance Spectroscopy for Breast Cancer Diagnosis During Core Needle Biopsy</btitle><date>2007-09</date><risdate>2007</risdate><notes>DTIC</notes><abstract>The goal of this project is to explore the potential of using tissue fluorescence and diffuse reflectance spectroscopy for breast cancer detection during a core needle breast biopsy. Both empirically based and model based approaches have been explored for the extraction of diagnostically useful information from the tissue spectra, as well as the diagnosis of breast cancer based on these extracted features. For the sample set investigated in our study, both intrinsic tissue properties extracted using model based approach and spectral features extracted using empirical spectral analysis could provide sensitivity and specificity of up to 89% for discriminating breast malignancy. These outcomes provided the foundation for using the optical sensor based on tissue fluorescence and diffuse reflectance spectroscopy as an adjunct diagnostic tool, which has the potential to provide guidance for core needle breast biopsy.</abstract><oa>free_for_read</oa></addata></record> |
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subjects | Atomic and Molecular Physics and Spectroscopy BIOPSY BREAST CANCER CORES DETECTION DIAGNOSIS(MEDICINE) DIAGNOSTIC EQUIPMENT DIFFUSE REFLECTANCE DIFFUSE REFLECTION DISCRIMINATION EXPERIMENTAL DATA EXTRACTION FLUORESCENCE MAMMARY GLANDS Medicine and Medical Research NEEDLES OPTICAL DETECTORS Optics SPECTRA SPECTROSCOPY SPECTRUM ANALYSIS |
title | Fluorescence and Diffuse Reflectance Spectroscopy for Breast Cancer Diagnosis During Core Needle Biopsy |
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