Fluorescence and Diffuse Reflectance Spectroscopy for Breast Cancer Diagnosis During Core Needle Biopsy

The goal of this project is to explore the potential of using tissue fluorescence and diffuse reflectance spectroscopy for breast cancer detection during a core needle breast biopsy. Both empirically based and model based approaches have been explored for the extraction of diagnostically useful info...

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Bibliographic Details
Main Author: Zhu, Changfang
Format: Report
Language:English
Subjects:
Atomic and Molecular Physics and Spectroscopy
BIOPSY
BREAST CANCER
CORES
DETECTION
DIAGNOSIS(MEDICINE)
DIAGNOSTIC EQUIPMENT
DIFFUSE REFLECTANCE
DIFFUSE REFLECTION
DISCRIMINATION
EXPERIMENTAL DATA
EXTRACTION
FLUORESCENCE
MAMMARY GLANDS
Medicine and Medical Research
NEEDLES
OPTICAL DETECTORS
Optics
SPECTRA
SPECTROSCOPY
SPECTRUM ANALYSIS
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Summary:The goal of this project is to explore the potential of using tissue fluorescence and diffuse reflectance spectroscopy for breast cancer detection during a core needle breast biopsy. Both empirically based and model based approaches have been explored for the extraction of diagnostically useful information from the tissue spectra, as well as the diagnosis of breast cancer based on these extracted features. For the sample set investigated in our study, both intrinsic tissue properties extracted using model based approach and spectral features extracted using empirical spectral analysis could provide sensitivity and specificity of up to 89% for discriminating breast malignancy. These outcomes provided the foundation for using the optical sensor based on tissue fluorescence and diffuse reflectance spectroscopy as an adjunct diagnostic tool, which has the potential to provide guidance for core needle breast biopsy.