Trichloromelamine 14-Day Range Finding and 90-Day Subchronic Studies in Rats. 3 August 1988 - 17 January 1989. Phase 2

The subchronic study examined the toxicity of the food service disinfectant trichloromelamine (TCM) in rats following oral administration-for 90 days. Associated with the administration of TCM in rats were lesions in the stomach and trachea, while also causing engorgement of the small blood vessels...

Full description

Saved in:
Bibliographic Details
Main Authors: Michie, Mark, Angerhofer, Richard A
Format: Report
Language:English
Subjects:
BLOOD VESSELS
BRAIN
DISINFECTANTS
FOOD SERVICE
HEALTH
KIDNEYS
LESIONS
LIVER
LUNG
MELAMIINE/TRICHLORO
RATS
STOMACH
TOXICITY
Toxicology
TRACHEA
TRICHLOROMELAMINE
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The subchronic study examined the toxicity of the food service disinfectant trichloromelamine (TCM) in rats following oral administration-for 90 days. Associated with the administration of TCM in rats were lesions in the stomach and trachea, while also causing engorgement of the small blood vessels of the adrenals, brain, kidneys, liver, lung and pituitary. The no observed adverse effect level in the 90-day study was 30 mg/kg/day. Trichloromelamine should be considered moderately toxic when ingested acutely, and continuous ingestion could cause serious health effects... Trichloromelamine, Toxicity, 14-Day, 90-Day.