Study of Compounds for Activity against Leishmania

During the period covered by this report, a total of 75 compounds were tested for efficacy against Leishmania donovani infections in hamsters. A computer analysis of the data from the study of approximately 6000 compounds tested since this project was initiated in 1974 suggested a number of compound...

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Bibliographic Details
Main Authors: Hanson, William L, Waits, V B, Chapman, W L , Jr
Format: Report
Language:English
Subjects:
8-AMINOQUINOLINES
AMINES
AMINOQUINOLINES
ANTILEISHMANIAL DRUGS
AS870
COMPUTER APPLICATIONS
DOSAGE
HAMSTERS
INFECTIOUS DISEASES
LEISHMANIA
LEISHMANIA DONOVANI
LEISHMANIASIS
LEVEL(QUANTITY)
METHANOLS
Microbiology
PE62787A
Pharmacology
PHENANTHRENES
QUINOLINES
TOXICITY
WR06026 ANTILEISHMANIAL DRUGS
WU037
WUDA335539
ZOONOTIC DISEASES
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Summary:During the period covered by this report, a total of 75 compounds were tested for efficacy against Leishmania donovani infections in hamsters. A computer analysis of the data from the study of approximately 6000 compounds tested since this project was initiated in 1974 suggested a number of compounds with sufficient promise to warrant further study during this contract period. The 8-aminoquinolines were the most active compounds studied, one of which was 100% suppressive at dosage levels as low as 13mg/kg. Six phenanthrene methanols as well as two dibenzopyrroles selected for study were not highly active against L. donovani, and some were toxic.