Aerosol and Intramuscular Prophylaxis of Respiratory 'Klebsiella pneumoniae' Infection in Mice and Squirrel Monkeys

Aerosol administration and intramuscular injection were compared for kanamycin prophylaxis against respiratory Klebsiella pneumoniae infection in both mice and squirrel monkeys. Mice challenged with an LD90 of Klebsiella 0.5, 4, 24, and 48 and 72 hours after aerosol treatment with 27 mg/kg of kanamy...

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Bibliographic Details
Main Authors: Berendt,Richard F, Schneider,Mark A, Young,Harold W, Frola,Frank R
Format: Report
Language:English
Subjects:
AEROSOLS
AS841
Biology
CLINICAL MEDICINE
INTRAMUSCULAR INJECTIONS
KLEBSIELLA PNEUMONIAE
MICE
PE62776A
PREVENTIVE MEDICINE
SQUIRREL MONKEYS
TEST METHODS
WU050
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Summary:Aerosol administration and intramuscular injection were compared for kanamycin prophylaxis against respiratory Klebsiella pneumoniae infection in both mice and squirrel monkeys. Mice challenged with an LD90 of Klebsiella 0.5, 4, 24, and 48 and 72 hours after aerosol treatment with 27 mg/kg of kanamycin were significantly better protected at all time periods than were mice given 450 mg/kg by IM injection. Squirrel monkeys given 11.25 mg/kg by aerosol were completely protected against Klebsiella challenge at 6 and 24 hours whereas only 1 of 8 monkeys injected IM with the same dose survived at 6 hours and none survived at 24 hours. Antibiotic clearance curves suggested that kanamycin remained in the lungs at higher concentrations and for a longer time after aerosol than after IM treatment. (Author)