HTLV-1 Tax Effects on Cellular Mitotic Regulation

The human T-cell leukemia virus 1 (HTLV-1) encodes the tax gene (transactivator encoded by the pX region) which is a potent activator of viral transcription and Nuclear Factor kappa B (NF-kB). Recent data indicate that Tax protein activates the anaphase promoting complex/cyclosome (APC) ahead of sch...

Full description

Saved in:
Bibliographic Details
Main Author: Merling,Randall K
Format: Report
Language:English
Subjects:
BIOSYNTHESIS
cancer
cells biology
DNA
gene expression
GLYCOPROTEINS
htlv-1(T-cell leukemia virus 1)
LEUKEMIA
Mitotic Regulation
MOLECULAR BIOLOGY
mutations
nf-kb(Nuclear Factor kappa B)
pathogenesis
retrovirus
Tax-mediated premature activation
TRANSCRIPTION GENETICS
viral transcription
Virology
viruses
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The human T-cell leukemia virus 1 (HTLV-1) encodes the tax gene (transactivator encoded by the pX region) which is a potent activator of viral transcription and Nuclear Factor kappa B (NF-kB). Recent data indicate that Tax protein activates the anaphase promoting complex/cyclosome (APC) ahead of schedule, thereby causing the premature degradation of cyclin A, cyclin B1, securin, and Skp2. The premature loss of these mitotic regulators is accompanied by mitotic aberrations and leads to rapid senescence and cell cycle arrest in HeLa and S. cerevisiae cells. This tax-induced rapid senescence (tax-IRS) of HeLa cells is mediated primarily through a dramatic stabilization of p27KIP, as deficiencies in p27KIP prevent Tax-IRS. Since p27KIP stabilization is accompanied by a surge in the level ofp21CIP1/WAF1, this cyclin-dependent kinase inhibitor may also play a role in tax-IRS.