The Effect of 6-Mev X-Ray on Plasma-Reducing Substances in the Primate (Macaca Mulatta)

Altered mammalian blood glucose levels following whole-body exposure to ionizing radiation have been well documented in the literature. Studies in the rat, guinea pig, and rabbit indicate that hyperglycemia follows irradiation after a period of hours to days. In contrast, in the primate, authors hav...

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Bibliographic Details
Main Authors: Beckman,Fred N, Craig,Dan J, Nathan,Marc A, Kinsley,Earl L
Format: Report
Language:English
Subjects:
BLOOD DISEASES
BLOOD PLASMA
GLUCOSE
PRIMATES
RADIATION EFFECTS
Radiobiology
WHOLE BODY IRRADIATION
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Summary:Altered mammalian blood glucose levels following whole-body exposure to ionizing radiation have been well documented in the literature. Studies in the rat, guinea pig, and rabbit indicate that hyperglycemia follows irradiation after a period of hours to days. In contrast, in the primate, authors have reported either no response to ionizing radiation or an early glucose 'burst.' Experiments were therefore undertaken which demonstrate: an early rise (30 to 50 mg. %) of plasma-reducing substances within 14 minutes after the onset of 165 rads/min. of 6-Mev x-irradiation; and blockage of this rise by diphenhydramine and alpha-chloralose. It is postulated that the early hyperglycemic response observed in the primate is much more closely related to the cardiovascular changes which occur immediately following ionizing radiation exposure than they are to gluconeogenesis and glycogenesis. (Author)