THE EFFECT OF COMPAZINE ON THE METABOLISM OF THE GERBIL

Oxygen consumption increases with a decrease in ambient temperature. At 18 C the control value for oxygen consumption was 3.49 ml O sub 2/gm/hr; at 26 C the control value was 2.88 ml O sub 2/gm/hr. Compazine depresses, at drug doses of 20 and 50 mg/kg, oxygen consumption at 18 C. Com pazine shows a...

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Bibliographic Details
Main Authors: Wilber, Charles G, Gardner, David L
Format: Report
Language:English
Subjects:
AUTONOMIC NERVOUS SYSTEM
COMPAZINE
DRUGS
METABOLISM
OXYGEN CONSUMPTION
Pharmacology
PHENOTHIAZINES
RODENTS
TEMPERATURE
TOXICITY
TRANQUILIZERS
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Summary:Oxygen consumption increases with a decrease in ambient temperature. At 18 C the control value for oxygen consumption was 3.49 ml O sub 2/gm/hr; at 26 C the control value was 2.88 ml O sub 2/gm/hr. Compazine depresses, at drug doses of 20 and 50 mg/kg, oxygen consumption at 18 C. Com pazine shows a depressant effect for 10, 20 and 50 mg/kg at the 26 C temperature. There is a pronounced rise in oxygen consumption at a drug dose of 60 mg/kg at both temperatures. Compazine, in doses of 90-100 mg/kg, begins to show toxicity effects, especially at the 26 C temperature. Statistical analysis (analysis of variance) reveals a definite interaction between drug concentration and temperature. Small desert rodents appear to have closely related metabolic rates as far as oxygen consumption is concerned.