In Vitro Antioxidant Activity of Purple Grape Juice (Vitis Labrusca) against Temozolamide Treatment in Rat Brains

In Vitro Antioxidant Activity of Purple Grape Juice (Vitis Labrusca) against Temozolamide Treatment in Rat Brains

Considering that grape juice has high levels of phenolic compounds that produce beneficial physiological effects, important for the maintenance of redox balance, the aim of this study was to evaluate the in vitro neuroprotective effect of purple grape juice on the oxidative damage caused by temozolo...

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Bibliographic Details
Published in:Beverages (Basel) 2018-12, Vol.4 (4), p.99
Main Authors: Gabardo, Tatiane, Frusciante, Marina Rocha, Pereira Marinho, Jessica, dos Santos, Manuela, Abujamra, Ana, Dani, Caroline, Funchal, Cláudia
Format: Article
Language:eng
Subjects:
antioxidant
Antioxidants
Brain
Carbohydrates
Catalase
Central nervous system
Cerebellum
Cerebral cortex
Fruit juices
Fruits
Grapes
Hippocampus
Incubation
Juices
Laboratory animals
Nervous system
Neuroprotection
Oxidation
Oxidative stress
Phenolic compounds
Phenols
Physiological effects
Proteins
Software
Superoxide dismutase
Temozolomide
Thiobarbituric acid
Variance analysis
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Summary:Considering that grape juice has high levels of phenolic compounds that produce beneficial physiological effects, important for the maintenance of redox balance, the aim of this study was to evaluate the in vitro neuroprotective effect of purple grape juice on the oxidative damage caused by temozolomide (TMZ) in the cerebral cortex, hippocampus, and cerebellum of Wistar rats. In pre-incubation, TMZ increased thiobarbituric acid reactive substances (TBARS) in the cerebral cortex and cerebellum, enhanced protein oxidation in all tissues studied, increased superoxide dismutase (SOD) activity in the hippocampus, decreased SOD activity in the cerebellum, and enhanced catalase (CAT) activity in the cerebral cortex and cerebellum. In co-incubation, there was enhanced protein oxidation in the cerebral cortex and cerebellum, decreased SOD activity in the cerebellum, inhibition of CAT activity in the hippocampus, and increased CAT activity in the cerebellum. Purple grape juice improved these oxidative alterations. Therefore, the intake of grape juice might have a protective effect against diseases that affect the oxidative status of the central nervous system.
ISSN:2306-5710
2306-5710