Crosstalk between Mitochondrial Protein Import and Lipids

Mitochondria import about 1000 precursor proteins from the cytosol. The translocase of the outer membrane (TOM complex) forms the major entry site for precursor proteins. Subsequently, membrane-bound protein translocases sort the precursor proteins into the outer and inner membrane, the intermembran...

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Bibliographic Details
Published in:	International journal of molecular sciences 2022-05, Vol.23 (9), p.5274
Main Authors:	Hoffmann, Juliane J, Becker, Thomas
Format:	Article
Language:	eng
Subjects:	Apoptosis Biosynthesis Crosstalk Cytosol Electron transport Fatty acids Imports Lipid bilayers Lipids Membrane potential Membrane proteins Membranes Mitochondria Phospholipid composition Phospholipids Phosphorylation Precursors protein import Protein transport Proteins Review SAM complex TOM complex Translocase
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Summary:	Mitochondria import about 1000 precursor proteins from the cytosol. The translocase of the outer membrane (TOM complex) forms the major entry site for precursor proteins. Subsequently, membrane-bound protein translocases sort the precursor proteins into the outer and inner membrane, the intermembrane space, and the matrix. The phospholipid composition of mitochondrial membranes is critical for protein import. Structural and biochemical data revealed that phospholipids affect the stability and activity of mitochondrial protein translocases. Integration of proteins into the target membrane involves rearrangement of phospholipids and distortion of the lipid bilayer. Phospholipids are present in the interface between subunits of protein translocases and affect the dynamic coupling of partner proteins. Phospholipids are required for full activity of the respiratory chain to generate membrane potential, which in turn drives protein import across and into the inner membrane. Finally, outer membrane protein translocases are closely linked to organellar contact sites that mediate lipid trafficking. Altogether, intensive crosstalk between mitochondrial protein import and lipid biogenesis controls mitochondrial biogenesis.
ISSN:	1422-0067 1661-6596 1422-0067