Outcomes of lung transplantation in adults with bronchiectasis

Lung transplantation is a well-established treatment for end-stage non-cystic fibrosis bronchiectasis (BR), though information regarding outcomes of transplantation remains limited. Our results of lung transplantation for Br are reported here. A retrospective review of case notes and transplantation...

Full description

Saved in:

Bibliographic Details
Published in:	BMC pulmonary medicine 2018-05, Vol.18 (1), p.82-82, Article 82
Main Authors:	Birch, Jodie, Sunny, Syba S, Hester, Katy L M, Parry, Gareth, Kate Gould, F, Dark, John H, Clark, Stephen C, Meachery, Gerard, Lordan, James, Fisher, Andrew J, Corris, Paul A, De Soyza, Anthony
Format:	Article
Language:	eng
Subjects:	Adult Adults Analysis Antibiotics Bacterial infections Biopsy Bronchiectasis Bronchiectasis - microbiology Bronchiectasis - mortality Bronchiectasis - surgery Care and treatment Cystic fibrosis Databases, Factual Disease Female Forced Expiratory Volume Heart Humans Infections Lung - physiopathology Lung Transplantation Male Medical prognosis Microbiology Middle Aged Morbidity Mortality Osteoporosis Patient outcomes Patients Postoperative Complications - epidemiology Pseudomonas Pseudomonas aeruginosa Pseudomonas infections Pseudomonas Infections - epidemiology Quality of life Respiratory function Retrospective Studies Sepsis Surveillance Survival Survival Analysis Syngeneic grafts Time Factors Transplantation Transplants & implants Treatment outcome Young Adult
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Lung transplantation is a well-established treatment for end-stage non-cystic fibrosis bronchiectasis (BR), though information regarding outcomes of transplantation remains limited. Our results of lung transplantation for Br are reported here. A retrospective review of case notes and transplantation databases was conducted for patients that had underwent lung transplantation for bronchiectasis at the Freeman Hospital between 1990 and 2013. Fourty two BR patients underwent lung transplantation, the majority (39) having bilateral sequential lung transplantation. Mean age at transplantation was 47.1 years. Pre-transplantation osteoporosis was a significant non-pulmonary morbidity (48%). Polymicrobial infection was common, with Pseudomonas aeruginosa infection frequently but not universally observed (67%). Forced expiratory volume in 1 second (% predicted) improved from a pre-transplantation mean of 0.71 L (22% predicted) to 2.56 L (79 % predicted) at 1-year post-transplantation. Our survival results were 74% at 1 year, 64% at 3 years, 61% at 5 years and 48% at 10 years. Sepsis was a common cause of early post-transplantation deaths. Lung transplantation for end-stage BR is a useful therapeutic option, with good survival and lung function outcomes. Survival values were similar to other bilateral lung transplants at our centre. Pre-transplantation Pseudomonas infection is common.
ISSN:	1471-2466 1471-2466