Effect of intensive weekend mindfulness-based intervention on BDNF, mitochondria function, and anxiety. A randomized, crossover clinical trial

Effect of intensive weekend mindfulness-based intervention on BDNF, mitochondria function, and anxiety. A randomized, crossover clinical trial

The previous metanalysis found that Mind-body intervention (MBI) improves neuropsychologic well-being and may increase brain-derived growth factor (BDNF). BDNF is a neurotrophic factor related to neuroplasticity. To evaluate the effect of the short intensive MBI compared to control-relaxation on Sit...

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Published in:Comprehensive Psychoneuroendocrinology (Online) 2022-08, Vol.11, p.100137-100137, Article 100137
Main Authors: Gomutbutra, Patama, Srikamjak, Tiam, Sapinun, Ladarat, Kunaphanh, Sukonta, Yingchankul, Nalinee, Apaijai, Nattayaporn, Shinlapawittayatorn, Krekwit, Phuackchantuck, Rochana, Chattipakorn, Nipon, Chattipakorn, Siriporn
Format: Article
Language:eng
Subjects:
Anxiety
BDNF
Clinical neuropsychiatry
Clinical science
Cortisol
HRV
Mindfulness Based Flow Practice
Mindfulness mechanism
Oxidative stress
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Summary:The previous metanalysis found that Mind-body intervention (MBI) improves neuropsychologic well-being and may increase brain-derived growth factor (BDNF). BDNF is a neurotrophic factor related to neuroplasticity. To evaluate the effect of the short intensive MBI compared to control-relaxation on Site on BDNF and examine if this change is related to mitochondria function or stress-related neurohormonal activity. Randomized, controlled, two-period cross-over trial conducted in a medical center in Thailand. Healthy-meditation naive Nurse and Occupational Therapy Students, 23 assigned randomly to MBI, and 24 relaxations at the site for 8 h during the weekend. The wash-out period was three months between the two periods. All volunteers took the blood test for BDNF, mitochondrial oxidative phosphorylation (OXPHOS), Cortisol, and Heart rate variability (HRV) measurement before and Visual Analogue Scale for Anxiety (VAS-A), forward and backward digit span after each period. A total of 40 participants finished the trials. The cross over trial analysis showed a significant treatment effect between MBI and Relaxation on-site for the mean VAS-A as 9.89 (95% CI 4.81 to 19.47; P = 0.001), serum BDNF as 1.24 (95% CI 0.16 to 2.32; P = 0.04), and OXPHOS complex-1 was decreased 0.41 (95% CI 0.03–0.29 p = 0.03). There were no significant differences for digit span, cortisol, and HRV. In healthy meditation naïve females, even a short period of MBI may increase serum BDNF and reduce anxiety more than relaxation on-site. The more reduction of OXPHOS complex-1 in the mindfulness group suggests oxidative stress may be a more sensitive indicator than stress-related neurohormonal activity. •The effects of a short, intensive mindfulness session are scarce.•Brain-derived growth factor (BDNF) is impacted by mindfulness-based intervention.•The results indicate that mindfulness practice increased BDNF.•This can be applied to the promotion of women's health.
ISSN:2666-4976
2666-4976