Alternatives for large-scale production of cultured beef：A review

Cultured beef is a method where stem cells from skeletal muscle of cows are cultured in vitro to gain edible muscle tissue. For large-scale production of cultured beef, the culture technique needs to become more efficient than today＇s 2-dimensional（2D） standard technique that was used to make the fi...

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Bibliographic Details
Published in:	Journal of Integrative Agriculture 2015-02, Vol.14 (2), p.208-216
Main Author:	Matilda S M Moritz, Sanne E L Verbruggen, Mark J Post (China National Hybrid Rice Research and Development Centre, Changsha 410125, P.R.China)
Format:	Article
Language:	eng
Subjects:	aggregated cells cell culture cultured beef cultured beef microcarriers aggregated cells packed bed bioreactor cell culture microcarriers packed bed bioreactor 填充床生物反应器大规模培养大规模生产替代品牛肉生产培养生产系统骨骼肌干细胞
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Summary:	Cultured beef is a method where stem cells from skeletal muscle of cows are cultured in vitro to gain edible muscle tissue. For large-scale production of cultured beef, the culture technique needs to become more efficient than today＇s 2-dimensional（2D） standard technique that was used to make the first cultured hamburger. Options for efficient large-scale production of stem cells are to culture cells on microcarriers, either in suspension or in a packed bed bioreactor, or to culture aggregated cells in suspension. We discuss the pros and cons of these systems as well as the possibilities to use the systems for tissue culture. Either of the production systems needs to be optimized to achieve an efficient production of cultured beef. It is anticipated that the optimization of large-scale cell culture as performed for other stem cells can be translated into successful protocols for bovine satellite cells resulting in resource and cost efficient cultured beef.
ISSN:	2095-3119 2352-3425