Prevalence, predictors, and management of advanced HIV disease among individuals initiating ART in Senegal, West Africa

The WHO guidelines for the management of advanced HIV disease recommend a package of care consisting of rapid initiation of antiretroviral therapy (ART), enhanced screening and diagnosis of tuberculosis (TB) and cryptococcal meningitis, co-trimoxazole prophylaxis, isoniazid preventive therapy (IPT),...

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Bibliographic Details
Published in:BMC infectious diseases 2019-03, Vol.19 (1), p.261-261, Article 261
Main Authors: Benzekri, Noelle A, Sambou, Jacques F, Ndong, Sanou, Tamba, Ibrahima Tito, Faye, Dominique, Diallo, Mouhamadou Baïla, Diatta, Jean Phillippe, Faye, Khadim, Sall, Ibrahima, Sall, Fatima, Manga, Noël Magloire, Malomar, Jean Jacques, Ndour, Cheikh T, Hawes, Stephen E, Seydi, Moussa, Gottlieb, Geoffrey S
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Advanced disease
AIDS
Antibiotics
Antifungal agents
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Antiretroviral therapy (ART)
Antitubercular agents
CD4 antigen
Cotrimoxazole
Cryptococcal meningitis
Diagnosis
Diagnostic systems
Disease control
Disease management
Drug therapy
Evaluation
Fluconazole
Future predictions
Guidelines
Health screening
Highly active antiretroviral therapy
HIV
HIV infections
HIV/AIDS
Human immunodeficiency virus
Isoniazid
Management
Management science
Medical research
Meningitis
Morbidity
Mortality
Operations research
Prevalence studies (Epidemiology)
Prevention
Preventive medicine
Preventive therapy
Prophylaxis
Public health
Regression analysis
Research funding
Risk factors
Screening
Signs and symptoms
Systematic review
Therapy
Tuberculosis
World Health Organization (WHO)
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Summary:The WHO guidelines for the management of advanced HIV disease recommend a package of care consisting of rapid initiation of antiretroviral therapy (ART), enhanced screening and diagnosis of tuberculosis (TB) and cryptococcal meningitis, co-trimoxazole prophylaxis, isoniazid preventive therapy (IPT), fluconazole pre-emptive therapy, and adherence support. The goals of this study were to determine the prevalence of advanced HIV disease among individuals initiating ART in Senegal, to identify predictors of advanced disease, and to evaluate adherence to the WHO guidelines. This study was conducted among HIV-positive individuals initiating ART in Dakar and Ziguinchor, Senegal. Clinical evaluations, laboratory analyses, questionnaires and chart review were conducted. Logistic regression was used to identify predictors of advanced disease. A total of 198 subjects were enrolled; 70% were female. The majority of subjects (71%) had advanced HIV disease, defined by the WHO as a CD4 count
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-019-3826-5