Electrically conductive carbon‐based (bio)‐nanomaterials for cardiac tissue engineering

A proper self‐regenerating capability is lacking in human cardiac tissue which along with the alarming rate of deaths associated with cardiovascular disorders makes tissue engineering critical. Novel approaches are now being investigated in order to speedily overcome the challenges in this path. Tis...

Full description

Saved in:

Bibliographic Details
Published in:	Bioengineering & translational medicine 2023-01, Vol.8 (1), p.e10347-n/a
Main Authors:	Jalilinejad, Negin, Rabiee, Mohammad, Baheiraei, Nafiseh, Ghahremanzadeh, Ramin, Salarian, Reza, Rabiee, Navid, Akhavan, Omid, Zarrintaj, Payam, Hejna, Aleksander, Saeb, Mohammad Reza, Zarrabi, Ali, Sharifi, Esmaeel, Yousefiasl, Satar, Zare, Ehsan Nazarzadeh
Format:	Article
Language:	eng
Subjects:	Atherosclerosis Biocompatibility Biomedical materials Carbon Carbon fibers Carbon nanotubes carbon‐based biomaterials cardiac tissue engineering Cardiovascular disease Catheters Conducting polymers Congenital diseases Coronary vessels Electrical resistivity Extracellular matrix Graphene graphene oxide Heart Literature reviews Mechanical properties Nanofibers Nanomaterials Nanoparticles Polymers Review scaffolds stem cells Substrates Surgical implants Tissue engineering Toxicity Vein & artery diseases
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	A proper self‐regenerating capability is lacking in human cardiac tissue which along with the alarming rate of deaths associated with cardiovascular disorders makes tissue engineering critical. Novel approaches are now being investigated in order to speedily overcome the challenges in this path. Tissue engineering has been revolutionized by the advent of nanomaterials, and later by the application of carbon‐based nanomaterials because of their exceptional variable functionality, conductivity, and mechanical properties. Electrically conductive biomaterials used as cell bearers provide the tissue with an appropriate microenvironment for the specific seeded cells as substrates for the sake of protecting cells in biological media against attacking mechanisms. Nevertheless, their advantages and shortcoming in view of cellular behavior, toxicity, and targeted delivery depend on the tissue in which they are implanted or being used as a scaffold. This review seeks to address, summarize, classify, conceptualize, and discuss the use of carbon‐based nanoparticles in cardiac tissue engineering emphasizing their conductivity. We considered electrical conductivity as a key affecting the regeneration of cells. Correspondingly, we reviewed conductive polymers used in tissue engineering and specifically in cardiac repair as key biomaterials with high efficiency. We comprehensively classified and discussed the advantages of using conductive biomaterials in cardiac tissue engineering. An overall review of the open literature on electroactive substrates including carbon‐based biomaterials over the last decade was provided, tabulated, and thoroughly discussed. The most commonly used conductive substrates comprising graphene, graphene oxide, carbon nanotubes, and carbon nanofibers in cardiac repair were studied.
ISSN:	2380-6761 2380-6761