Engineering chromosome rearrangements in cancer

The identification of large chromosomal rearrangements in cancers has multiplied exponentially over the last decade. These complex and often rare genomic events have traditionally been challenging to study, in part owing to lack of tools that efficiently engineer disease-associated inversions, delet...

Full description

Saved in:

Bibliographic Details
Published in:	Disease models & mechanisms 2021-09, Vol.14 (9)
Main Authors:	Alonso, Salvador, Dow, Lukas E
Format:	Article
Language:	eng
Subjects:	Cancer Cancer therapies Chemotherapy chromosomal rearrangements Chromosome Aberrations Chromosomes Clinical trials CRISPR Editing fusion oncogenes Gene Editing Gene expression Gene Rearrangement - genetics Genetic engineering Genome Genomes Humans Kinases Laboratories Medical research Mutation Neoplasms - genetics Patients Response rates Review
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The identification of large chromosomal rearrangements in cancers has multiplied exponentially over the last decade. These complex and often rare genomic events have traditionally been challenging to study, in part owing to lack of tools that efficiently engineer disease-associated inversions, deletions and translocations in model systems. The emergence and refinement of genome editing technologies, such as CRISPR, have significantly expanded our ability to generate and interrogate chromosomal aberrations to better understand the networks that govern cancer growth. Here we review how existing technologies are employed to faithfully model cancer-associated chromosome rearrangements in the laboratory, with the ultimate goal of developing more accurate pre-clinical models of and therapeutic strategies for cancers driven by these genomic events.
ISSN:	1754-8403 1754-8411