The Diagnostic Value of CEUS in Assessing Non-Ossified Thyroid Cartilage Invasion in Patients with Laryngeal Squamous Cell Carcinoma

Accurate assessment of thyroid cartilage invasion in squamous cell carcinoma (SCC) of the larynx remains a challenge in clinical practice. The aim of this study was to assess the diagnostic performance of contrast-enhanced ultrasound (CEUS), contrast-enhanced computed tomography (CECT), and magnetic...

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Bibliographic Details
Published in:	Journal of clinical medicine 2024-02, Vol.13 (3), p.891
Main Authors:	Pucėtaitė, Milda, Farina, Davide, Ryškienė, Silvija, Mitraitė, Dalia, Tarasevičius, Rytis, Lukoševičius, Saulius, Padervinskis, Evaldas, Vaitkus, Saulius
Format:	Article
Language:	eng
Subjects:	Accuracy Algorithms Care and treatment Cartilage CECT CEUS CT imaging Diagnosis Diagnostic imaging Evaluation Laryngeal cancer Larynx Magnetic resonance imaging MRI non-ossified thyroid cartilage Patients Scanners Squamous cell carcinoma Surgery Swallowing Thyroid gland Tomography
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Summary:	Accurate assessment of thyroid cartilage invasion in squamous cell carcinoma (SCC) of the larynx remains a challenge in clinical practice. The aim of this study was to assess the diagnostic performance of contrast-enhanced ultrasound (CEUS), contrast-enhanced computed tomography (CECT), and magnetic resonance imaging (MRI) in the detection of non-ossified thyroid cartilage invasion in patients with SCC. CEUS, CECT, and MRI scans of 27 male patients with histologically proven SCC were evaluated and compared. A total of 31 cases were assessed via CEUS and CECT. The MR images of five patients and six cases were excluded (one patient had two suspected sites), leaving twenty-five cases for analysis via MRI. CEUS showed the highest accuracy and specificity compared with CECT and MRI (87.1% vs. 64.5% and 76.0% as well as 84.0% vs. 64.0% and 72.7%, respectively). The sensitivity and negative predictive value of CEUS and MRI were the same (100%). CEUS yielded four false-positive findings. However, there were no statistically significant differences among the imaging modalities ( > 0.05). CEUS showed better diagnostic performance than CECT and MRI. Therefore, CEUS has the potential to accurately assess non-ossified thyroid cartilage invasion and guide appropriate treatment decisions, hopefully leading to improved patient outcomes.
ISSN:	2077-0383 2077-0383