Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays

FANCI:FANCD2 monoubiquitination is a critical event for replication fork stabilization by the Fanconi anemia (FA) DNA repair pathway. It has been proposed that at stalled replication forks, monoubiquitinated-FANCD2 serves to recruit DNA repair proteins that contain ubiquitin-binding motifs. Here, we...

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Bibliographic Details

Published in:	eLife 2020-03, Vol.9
Main Authors:	Tan, Winnie, van Twest, Sylvie, Leis, Andrew, Bythell-Douglas, Rohan, Murphy, Vincent J, Sharp, Michael, Parker, Michael W, Crismani, Wayne, Deans, Andrew J
Format:	Article
Language:	eng
Subjects:	Anemia Binding sites biochemistry Bone marrow Chromosomes and Gene Expression Deoxyribonucleic acid DNA DNA Damage DNA Repair DNA Replication Electron microscopy Fanconi anemia Fanconi Anemia Complementation Group D2 Protein - genetics Fanconi Anemia Complementation Group D2 Protein - metabolism Fanconi Anemia Complementation Group Proteins - genetics Fanconi Anemia Complementation Group Proteins - metabolism Fanconi syndrome Humans Protein interaction Proteins Replication forks Ubiquitin Ubiquitination
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