An Implantable Magneto-Responsive Poly(aspartamide) Based Electrospun Scaffold for Hyperthermia Treatment

When exposed to an alternating magnetic field, superparamagnetic nanoparticles can elicit the required hyperthermic effect while also being excellent magnetic resonance imaging (MRI) contrast agents. Their main drawback is that they diffuse out of the area of interest in one or two days, thus preven...

Full description

Saved in:
Bibliographic Details
Published in:Nanomaterials (Basel, Switzerland) Switzerland), 2022-04, Vol.12 (9), p.1476
Main Authors: Veres, Tamás, Voniatis, Constantinos, Molnár, Kristóf, Nesztor, Dániel, Fehér, Daniella, Ferencz, Andrea, Gresits, Iván, Thuróczy, György, Márkus, Bence Gábor, Simon, Ferenc, Nemes, Norbert Marcell, García-Hernández, Mar, Reiniger, Lilla, Horváth, Ildikó, Máthé, Domokos, Szigeti, Krisztián, Tombácz, Etelka, Jedlovszky-Hajdu, Angela
Format: Article
Language:English
Subjects:
Alternating current
Apoptosis
Biocompatibility
Biodegradability
Biodegradation
Cancer therapies
Cell adhesion & migration
Cell growth
Chemical synthesis
Chloride
Contrast agents
Contrast media
electrospinning
Fever
Fibers
Fourier transforms
Heat generation
Hydrogels
Hyperthermia
In vivo methods and tests
Infrared spectroscopy
Iron oxides
Magnetic fields
magnetic iron oxide nanoparticles
Magnetic properties
Magnetic resonance imaging
Magnetite
Membranes
MRI
Nanoparticles
Polymers
polysuccinimide
Reagents
Scaffolds
Spectrum analysis
Superconducting quantum interference devices
theranostics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:When exposed to an alternating magnetic field, superparamagnetic nanoparticles can elicit the required hyperthermic effect while also being excellent magnetic resonance imaging (MRI) contrast agents. Their main drawback is that they diffuse out of the area of interest in one or two days, thus preventing a continuous application during the typical several-cycle multi-week treatment. To solve this issue, our aim was to synthesise an implantable, biodegradable membrane infused with magnetite that enabled long-term treatment while having adequate MRI contrast and hyperthermic capabilities. To immobilise the nanoparticles inside the scaffold, they were synthesised inside hydrogel fibres. First, polysuccinimide (PSI) fibres were produced by electrospinning and crosslinked, and then, magnetitc iron oxide nanoparticles (MIONs) were synthesised inside and in-between the fibres of the hydrogel membranes with the well-known co-precipitation method. The attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) investigation proved the success of the chemical synthesis and the presence of iron oxide, and the superconducting quantum interference device (SQUID) study revealed their superparamagnetic property. The magnetic hyperthermia efficiency of the samples was significant. The given alternating current (AC) magnetic field could induce a temperature rise of 5 °C (from 37 °C to 42 °C) in less than 2 min even for five quick heat-cool cycles or for five consecutive days without considerable heat generation loss in the samples. Short-term (1 day and 7 day) biocompatibility, biodegradability and MRI contrast capability were investigated in vivo on Wistar rats. The results showed excellent MRI contrast and minimal acute inflammation.
ISSN:2079-4991
2079-4991
DOI:10.3390/nano12091476