Leptin as a Predictive Marker in Unexplained Infertility in North Indian Population

According to WHO, the primary infertility in India is about 3.9% (age-standardized to 25-49 year) and 16.8% (age-standardized to 15-49 year), using the "age but no birth" definition. Several factors which affect fertility include low sperm production in men, poor egg quality and blocked fa...

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Bibliographic Details
Published in:	Journal of clinical and diagnostic research 2017-03, Vol.11 (3), p.QC28-QC31
Main Authors:	Kumari, Pratibha, Jaiswar, S P, Shankhwar, Pushplata, Deo, Sujata, Ahmad, Kalim, Iqbal, Bushra, Mahdi, A A
Format:	Article
Language:	eng
Subjects:	body mass index neuroendocrine obesity Obstetrics and Gynaecology Section reproduction serum leptin unexplained infertility
Online Access:	Get full text
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Summary:	According to WHO, the primary infertility in India is about 3.9% (age-standardized to 25-49 year) and 16.8% (age-standardized to 15-49 year), using the "age but no birth" definition. Several factors which affect fertility include low sperm production in men, poor egg quality and blocked fallopian tubes in women and also hormonal imbalances. Leptin plays a critical role in women's reproduction and neuroendocrine health. It is used for treating exercise-induced bone loss, eating disorders and infertility. To evaluate the serum leptin levels in Indians and to ascertain the relationship between serum leptin levels, Unexplained Infertility (UI) and related variables [height, weight, Waist Hip Ratio (WHR), Body Mass Index (BMI)] between obese infertile, non-obese infertile and healthy subjects. The present case-control study was conducted at the Department of Obstetrics and Gynaecology, King George's Medical University (KGMU), Lucknow, India and funded by Department of Science and Technology, New Delhi, India. The study included 229 female participants in the age group of 18-40 years (120 cases and 109 controls) who were randomly selected. The blood samples were collected from the Infertility Clinic, Queen Mary's Hospital, KGMU, Lucknow, India. All the participants underwent complete physical examination. Initially, the participants were categorized into fertile and infertile groups, they were further divided on the basis of BMI, normal (BMI- 18.5-24.5) and overweight or obese (BMI≥25). Leptin level was measured by Active Human Leptin ELISA kit and BMI of all subjects was calculated in kg/m (weight in kg and height in m). A highly positive linear correlation (R=0.754, p
ISSN:	2249-782X 0973-709X