Effects of evolocumab therapy and low LDL‐C levels on vitamin E and steroid hormones in Chinese and global patients with type 2 diabetes

Effects of evolocumab therapy and low LDL‐C levels on vitamin E and steroid hormones in Chinese and global patients with type 2 diabetes

Aims We assessed the change from baseline in vitamin E, steroid hormones, adrenocorticotropic hormone (ACTH), and gonadotropins, overall and by lowest achieved low‐density lipoprotein‐cholesterol (LDL‐C) level, in patients with type 2 diabetes and dyslipidaemia after 12 weeks of treatment with evolo...

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Published in:Endocrinology, diabetes & metabolism diabetes & metabolism, 2020-04, Vol.3 (2), p.e00123-n/a
Main Authors: Blom, Dirk J., Chen, Jiyan, Yuan, Zuyi, Borges, Joao L. C., Monsalvo, Maria L., Wang, Nan, Hamer, Andrew W., Ge, Junbo
Format: Article
Language:eng
Subjects:
Cardiovascular disease
Cholesterol
Clinical trials
Diabetes
Drug dosages
dyslipidaemia
hypercholesterolaemia
Laboratories
Metabolism
Original
Oxidative stress
Patients
PCSK9 inhibitor
Testosterone
Vitamin E
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Summary:Aims We assessed the change from baseline in vitamin E, steroid hormones, adrenocorticotropic hormone (ACTH), and gonadotropins, overall and by lowest achieved low‐density lipoprotein‐cholesterol (LDL‐C) level, in patients with type 2 diabetes and dyslipidaemia after 12 weeks of treatment with evolocumab. Materials and Methods This was a prespecified analysis of vitamin E, cortisol, ACTH, gonadal hormones and gonadotropins in the 12‐week, placebo‐controlled BERSON trial of evolocumab in patients with type 2 diabetes and dyslipidaemia. In BERSON, 981 (451 in China) patients on daily atorvastatin 20 mg were randomized to placebo or one of two doses of evolocumab. We measured analyte levels at baseline and week 12 (vitamin E in all patients; steroid/gonadal hormones only in Chinese patients). Results In both the global and Chinese populations, absolute vitamin E levels decreased from baseline to week 12 by approximately 6 μmol/L (P 
ISSN:2398-9238
2398-9238