Molecular adaptations underlying high-frequency hearing in the brain of CF bats species

Molecular adaptations underlying high-frequency hearing in the brain of CF bats species

The majority of bat species have developed remarkable echolocation ability, especially for the laryngeally echolocating bats along with high-frequency hearing. Adaptive evolution has been widely detected for the cochleae in the laryngeally echolocating bats, however, limited understanding for the br...

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Bibliographic Details
Published in:BMC genomics 2024-03, Vol.25 (1), p.279-279
Main Authors: Li, Xintong, Wang, Hui, Wang, Xue, Bao, Mingyue, Sun, Ruyi, Dai, Wentao, Sun, Keping, Feng, Jiang
Format: Article
Language:eng
Subjects:
Acoustics
Adaptation
Adaptive evolution
Analysis
Animals
Archives & records
Auditory perception
Bats
Brain
Chiroptera - genetics
Echolocation
Echolocation - physiology
Evaluation
Evolution
Evolution & development
Gene expression
Genes
Genetic transcription
Hearing
Hearing - genetics
Information processing
Myotis pilosus
Nervous system
Physiology
Rhinolophus ferrumequinum
RNA-Seq
Signal processing
Signal transduction
Sound waves
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Summary:The majority of bat species have developed remarkable echolocation ability, especially for the laryngeally echolocating bats along with high-frequency hearing. Adaptive evolution has been widely detected for the cochleae in the laryngeally echolocating bats, however, limited understanding for the brain which is the central to echolocation signal processing in the auditory perception system, the laryngeally echolocating bats brain may also undergo adaptive changes. In order to uncover the molecular adaptations related with high-frequency hearing in the brain of laryngeally echolocating bats, the genes expressed in the brain of Rhinolophus ferrumequinum (CF bat) and Myotis pilosus (FM bat) were both detected and also compared. A total of 346,891 genes were detected and the signal transduction mechanisms were annotated by the most abundant genes, followed by the transcription. In hence, there were 3,088 DEGs were found between the two bat brains, with 1,426 highly expressed in the brain of R. ferrumequinum, which were significantly enriched in the neuron and neurodevelopmental processes. Moreover, we found a key candidate hearing gene, ADCY1, playing an important role in the R. ferrumequinum brain and undergoing adaptive evolution in CF bats. Our study provides a new insight to the molecular bases of high-frequency hearing in two laryngeally echolocating bats brain and revealed different nervous system activities during auditory perception in the brain of CF bats.
ISSN:1471-2164
1471-2164