Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance

Antimicrobial peptides (AMPs) are promising antimicrobials, however, the potential of bacterial resistance is a major concern. Here we systematically study the evolution of resistance to 14 chemically diverse AMPs and 12 antibiotics in Escherichia coli. Our work indicates that evolution of resistanc...

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Bibliographic Details

Published in:	Nature communications 2019-10, Vol.10 (1), p.4538-13, Article 4538
Main Authors:	Spohn, Réka, Daruka, Lejla, Lázár, Viktória, Martins, Ana, Vidovics, Fanni, Grézal, Gábor, Méhi, Orsolya, Kintses, Bálint, Számel, Mónika, Jangir, Pramod K, Csörgő, Bálint, Györkei, Ádám, Bódi, Zoltán, Faragó, Anikó, Bodai, László, Földesi, Imre, Kata, Diána, Maróti, Gergely, Pap, Bernadett, Wirth, Roland, Papp, Balázs, Pál, Csaba
Format:	Article
Language:	eng
Subjects:	Anti-Infective Agents - pharmacology Antibiotic resistance Antibiotics Antiinfectives and antibacterials Antimicrobial agents Antimicrobial Cationic Peptides - pharmacology Antimicrobial Cationic Peptides - therapeutic use Antimicrobial peptides Bacteria Bacteria - drug effects Bacteria - genetics Bacterial Infections - drug therapy Cecropin Cross-resistance Directed Molecular Evolution Drug development Drug Development - methods Drug Resistance, Multiple, Bacterial - drug effects Drug Resistance, Multiple, Bacterial - genetics E coli Evolution Gene amplification Genome, Bacterial - drug effects Genome, Bacterial - genetics Humans Immune system Innate immunity Metagenomics Microbial Sensitivity Tests Mutation Organic chemistry Peptides Plasmids Plasmids - genetics Point Mutation Soil bacteria Soil Microbiology Soil microorganisms
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