VCAM-1 Is Upregulated in Uranium Miners Compared to Other Miners

The United States has a rich history of mining including uranium (U)-mining, coal mining, and other metal mining. Cardiovascular diseases (CVD) are largely understudied in miners and recent literature suggests that when compared to non-U miners, U-miners are more likely to report CVD. However, the m...

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Bibliographic Details
Published in:	Life (Basel, Switzerland) Switzerland), 2021-11, Vol.11 (11), p.1223
Main Authors:	Ass'ad, Nour A, Shore, Xin, Myers, Orrin, Camacho, Alexandra R, Jacquez, Quiteria, Pollard, Charles, Cook, Linda S, Leng, Shuguang, Page, Kimberly, Sood, Akshay, Zychowski, Katherine E
Format:	Article
Language:	eng
Subjects:	Adhesion Amyloid Biological assays Biomarkers Blood pressure Body mass index cardiovascular Cardiovascular disease Cardiovascular diseases Cell adhesion Cell adhesion molecules Chemokines Cholesterol Chronology Coal mining Coronary vessels Cytokines Gene expression Glucose High density lipoprotein Hypertension Inflammation Insulin resistance Intercellular adhesion molecule 1 Ligands Miners Mining Mining industry Mortality Statistical analysis Tenure Tumor necrosis factor-TNF Uranium Vascular cell adhesion molecule 1 VCAM-1
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Summary:	The United States has a rich history of mining including uranium (U)-mining, coal mining, and other metal mining. Cardiovascular diseases (CVD) are largely understudied in miners and recent literature suggests that when compared to non-U miners, U-miners are more likely to report CVD. However, the molecular basis for this phenomenon is currently unknown. In this pilot study, a New Mexico (NM)-based occupational cohort of current and former miners ( = 44) were recruited via a mobile screening clinic for miners. Serum- and endothelial-based endpoints were used to assess circulating inflammatory potential relevant to CVD. Non-U miners reported significantly fewer pack years of smoking than U-miners. Circulating biomarkers of interest revealed that U-miners had significantly greater serum amyloid A (SAA), soluble intercellular adhesion molecule 1 (ICAM-1, ng/mL), soluble vascular cell adhesion molecule 1 (VCAM-1, ng/mL), and VCAM-1 mRNA expression, as determined by the serum cumulative inflammatory potential (SCIP) assay, an endothelial-based assay. Even after adjusting for various covariates, including age, multivariable analysis determined that U-miners had significantly upregulated VCAM-1 mRNA. In conclusion, VCAM-1 may be an important biomarker and possible contributor of CVD in U-miners. Further research to explore this mechanism may be warranted.
ISSN:	2075-1729 2075-1729