Clinic friendly estimation of muscle composition: Preoperative linear segmentation shows overall survival correlated with muscle mass in patients with nonmetastatic renal cell carcinoma

Clinic friendly estimation of muscle composition: Preoperative linear segmentation shows overall survival correlated with muscle mass in patients with nonmetastatic renal cell carcinoma

Sarcopenia is associated with decreased survival and increased complications in patients with renal cell carcinoma. Readily identifying patients with low muscle composition that may experience worse outcomes or would benefit from preoperative intervention is of clinical interest. Traditional body co...

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Bibliographic Details
Published in:Frontiers in oncology 2022-11, Vol.12, p.1068357-1068357
Main Authors: Schmeusser, Benjamin N, Midenberg, Eric, Palacios, Arnold R, Vettikattu, Nikhil, Patil, Dattatraya H, Medline, Alexandra, Higgins, Michelle, Armas-Phan, Manuel, Nabavizadeh, Reza, Joshi, Shreyas S, Narayan, Vikram M, Psutka, Sarah P, Ogan, Kenneth, Bilen, Mehmet A, Master, Viraj A
Format: Article
Language:eng
Subjects:
linear segmentation
muscle composition
muscle mass
nephrectomy
Oncology
renal cell carcinoma
sarcopenia
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Summary:Sarcopenia is associated with decreased survival and increased complications in patients with renal cell carcinoma. Readily identifying patients with low muscle composition that may experience worse outcomes or would benefit from preoperative intervention is of clinical interest. Traditional body composition analysis methods are resource intensive; therefore, linear segmentation with routine imaging has been proposed as a clinically practical alternative. This study assesses linear segmentation's prognostic utility in nonmetastatic renal cell carcinoma. A single institution retrospective analysis of patients that underwent nephrectomy for nonmetastatic renal cell carcinoma from 2005-2021 was conducted. Linear segmentation of the bilateral psoas/paraspinal muscles was completed on preoperative imaging. Total muscle area and total muscle index associations with overall survival were determined by multivariable analysis. 532 (388 clear cell) patients were analyzed, with median (IQR) total muscle index of 28.6cm /m (25.8-32.5) for women and 33.3cm /m (29.1-36.9) for men. Low total muscle index was associated with decreased survival (HR=1.96, 95% CI 1.32-2.90, p
ISSN:2234-943X
2234-943X