Evaluation of the Involvement of Heme Oxygenase-1 Expression in Discoid Lupus Erythematosus Lesions

Evaluation of the Involvement of Heme Oxygenase-1 Expression in Discoid Lupus Erythematosus Lesions

Discoid lupus erythematosus (DLE) is a chronic autoimmune disease that primarily affects the skin, causing red, scaly patches that may be disfiguring and can cause permanent scarring. This study aimed to investigate the potential clinical and therapeutic applications of heme oxygenase-1 (HMOX1) in t...

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Bibliographic Details
Published in:Antioxidants 2023-06, Vol.12 (7), p.1352
Main Authors: Fagone, Paolo, Piombino, Eliana, Mangano, Katia, De Pasquale, Rocco, Nicoletti, Ferdinando, Caltabiano, Rosario
Format: Article
Language:eng
Subjects:
Analysis
Antibodies
Antioxidants
Antiparasitic agents
Atrophy
Autoimmune diseases
B cells
Bioinformatics
Biopsy
Carbon monoxide
Discoid lupus erythematosus
Disease
Enzymes
Health aspects
Heme
Heme oxygenase (decyclizing)
HMOX1
Immunohistochemistry
Inflammation
Laboratories
Lupus
Macrophages
Oxidative stress
Skin
skin diseases
Therapeutic applications
Therapeutic targets
Type 2 diabetes
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Summary:Discoid lupus erythematosus (DLE) is a chronic autoimmune disease that primarily affects the skin, causing red, scaly patches that may be disfiguring and can cause permanent scarring. This study aimed to investigate the potential clinical and therapeutic applications of heme oxygenase-1 (HMOX1) in the context of DLE. Immunohistochemical staining and bioinformatics analysis were performed on skin biopsy samples from DLE patients to examine the levels of HMOX1 and to correlate with markers of inflammation. Our study revealed a negative correlation between HMOX1 levels and the inflammatory status of DLE lesions, as well as an inverse correlation between HMOX1 levels and the infiltration of M1 macrophages and activated mastocytes. These findings suggest that HMOX1 plays a crucial role in the regulation of inflammation in DLE and could be a potential therapeutic target and biomarker for DLE.
ISSN:2076-3921
2076-3921