Cutaneous Infantile Haemangiomas with Intracranial and Intraspinal Involvement: A European Multicentre Experience and Review

Infantile haemangiomas are very common benign tumours in the first months of life. They are mostly cutaneous; however, extracutaneous lesions are possible, and occur in very rare cases in the central nervous system. A European multicentre observational retrospective study was conducted in the last 5...

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Bibliographic Details
Published in:	Acta dermato-venereologica 2020-09, Vol.100 (16), p.adv00255-adv00255
Main Authors:	Diociaiuti, Andrea, Carnevale, Claudia, Torres, Eulalia Baselga, Léauté-Labrèze, Christine, Neri, Iria, Rotunno, Roberta, Figà-Talamanca, Lorenzo, El Hachem, May
Format:	Article
Language:	eng
Subjects:	Adrenergic beta-Antagonists central nervous system Clinical Report Hemangioma - drug therapy Hemangioma, Capillary Humans Infant infantile haemangioma oral propranolol Propranolol - therapeutic use Retrospective Studies Skin Neoplasms - drug therapy
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Summary:	Infantile haemangiomas are very common benign tumours in the first months of life. They are mostly cutaneous; however, extracutaneous lesions are possible, and occur in very rare cases in the central nervous system. A European multicentre observational retrospective study was conducted in the last 5 years. Seven patients with intracranial or intraspinal infantile haemangiomas were selected and treated with oral propranolol. Propranolol was interrupted after complete or almost complete resolution of infantile haemangiomas. All patients tolerated the treatment well without side-effects. Central nervous system infantile haemangiomas are probably underestimated due to the frequent absence of symptoms and their spontaneous involution. However, they should be investigated in case of segmental cutaneous infantile haemangiomas, particularly on the head, neck, upper trunk, lumbar or sacral area in order to diagnosis intra-central nervous system involvement at an early stage.
ISSN:	1651-2057 0001-5555 1651-2057