Evaluation of Therapeutic Effectiveness of Prescribed Medications in Patients with Type 2 Diabetes Mellitus: Findings from a Tertiary Care Hospital, Lahore, Pakistan

The present study was aimed to highlight the current prescribing pattern of oral hypoglycemia in type 2 diabetes mellitus and to evaluate the therapeutic effectiveness of these therapeutic categories in achieving target glycemic control. This is a prospective, cross-sectional, observational study of...

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Published in:	Journal of pharmacy & bioallied science 2017-04, Vol.9 (2), p.121-125
Main Authors:	Rana, Bareera, Bukhsh, Allah, Khan, Tahir Mehmood, Sarwar, Ammar, Omer, Muhammad Ovais, Jamshed, Shazia Qasim
Format:	Article
Language:	eng
Subjects:	Age Animal sciences Care and treatment Child development Chronic illnesses Diabetes Diabetes mellitus Diagnosis Dosage and administration Drug dosages Females glycated hemoglobin Hemoglobin Hospitals Hypoglycemia Hypoglycemic agents Insulin Laboratories Lahore Males Metabolism Metformin Morisky score Neuropathy Original Pakistan Pharmaceutical sciences Pharmacy prescribing trends Studies Type 2 diabetes Values
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Summary:	The present study was aimed to highlight the current prescribing pattern of oral hypoglycemia in type 2 diabetes mellitus and to evaluate the therapeutic effectiveness of these therapeutic categories in achieving target glycemic control. This is a prospective, cross-sectional, observational study of 6 months' duration conducted in a tertiary care hospital of Lahore, Pakistan. The current research recruited 145 patients presented in diabetes management center of a tertiary care hospital in Lahore, Pakistan. Mean age of the participants was 50.2 (± 8.5) years. Out of the 145 patients, 63% were females and 37% were males. Most patients were diagnosed to have diabetes within the past 5 years. Diabetes-induced neuropathy was the most common complication (71.7%) among the patients. A large proportion of these patients (70.3%) were also suffering from other comorbidities among which the most common one is hypertension. The average number of prescribed medications was 1.31. Metformin was prescribed to a majority of patients (64%) as monotherapy while 28.96% received combination therapy. Mean glycated hemoglobin (HBA1c) before and after 3 months of treatment was 8.5 (± 2.3) and 8.04 (± 2.1), respectively. Inferential statistics show a strong association between HBA1c and life style modifications and adherence to medication therapy ( = 0.05). However, the correlation between HBA1c and Morisky score and duration of disease was inverse and weak ( = 0.6, 0.4). The -test values show a small difference between HBA1c values before and after 3 months ( = 0.440 and 0.466, respectively). Optimization of medication regimen and continuous patient education regarding life style modification and adherence to medication therapy are necessitated to bring HBA1c values near to target.
ISSN:	0976-4879 0975-7406 0975-7406