GDF15 is an exercise-induced hepatokine regulated by glucagon and insulin in humans

Growth differentiation factor (GDF)-15 is implicated in regulation of metabolism and circulating GDF15 increases in response to exercise. The source and regulation of the exercise-induced increase in GDF15 is, however not known. Plasma GDF15 was measured by ELISA under the following conditions: 1) A...

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Published in:	Frontiers in endocrinology (Lausanne) 2022-12, Vol.13, p.1037948-1037948
Main Authors:	Plomgaard, Peter, Hansen, Jakob S, Townsend, Logan K, Gudiksen, Anders, Secher, Niels H, Clemmesen, Jens O, Støving, Rene K, Goetze, Jens P, Wright, David C, Pilegaard, Henriette
Format:	Article
Language:	eng
Subjects:	Animals anorexia nervosa appetite Endocrinology fasting Glucagon - metabolism Growth Differentiation Factor 15 - metabolism Humans Insulin - metabolism insulin resistance liver Male Mice Pancreas - metabolism Pancreatic Hormones RNA, Messenger splanchnic bed
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Summary:	Growth differentiation factor (GDF)-15 is implicated in regulation of metabolism and circulating GDF15 increases in response to exercise. The source and regulation of the exercise-induced increase in GDF15 is, however not known. Plasma GDF15 was measured by ELISA under the following conditions: 1) Arterial-to-hepatic venous differences sampled before, during, and after exercise in healthy male subjects (n=10); 2) exogenous glucagon infusion compared to saline infusion in resting healthy subjects (n=10); 3) an acute exercise bout with and without a pancreatic clamp (n=6); 4) healthy subjects for 36 hours (n=17), and 5) patients with anorexia nervosa (n=25) were compared to healthy age-matched subjects (n=25). Tissue GDF15 mRNA content was determined in mice in response to exhaustive exercise (n=16). The splanchnic bed released GDF15 to the circulation during exercise and increasing the glucagon-to-insulin ratio in resting humans led to a 2.7-fold (P
ISSN:	1664-2392 1664-2392