A Survey on the Synthesis of Variolins, Meridianins, and Meriolins-Naturally Occurring Marine (aza)Indole Alkaloids and Their Semisynthetic Derivatives

A Survey on the Synthesis of Variolins, Meridianins, and Meriolins-Naturally Occurring Marine (aza)Indole Alkaloids and Their Semisynthetic Derivatives

Marine natural products are a source of essential significance due to a plethora of highly diverse biological properties. The naturally occurring (aza)indole alkaloids variolin B ( ), meridianins ( ), and their synthetic hybrids meriolins ( ) exhibit potent kinase inhibitory activities and have arou...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-01, Vol.28 (3), p.947
Main Authors: Kruppa, Marco, Müller, Thomas J J
Format: Article
Language:eng
Subjects:
Alkaloids
Anderson, R.J
Biological activity
Biological properties
Cell cycle
Colorectal cancer
Cyclin-dependent kinases
Cytotoxicity
Gases industry
Hybrids
indole alkaloids
Indole Alkaloids - chemistry
Kinases
Leukemia
marine natural products
meridianins
meriolins
natural product syntheses
Natural products
Phosphorylation
Plant metabolites
Proteins
Review
Surveys
variolins
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Summary:Marine natural products are a source of essential significance due to a plethora of highly diverse biological properties. The naturally occurring (aza)indole alkaloids variolin B ( ), meridianins ( ), and their synthetic hybrids meriolins ( ) exhibit potent kinase inhibitory activities and have aroused considerable interest in the past two decades. Therefore, the immense demand for versatile synthetic accesses to these structures has considerably increased. This review surveys the synthetic pathways to these naturally occurring alkaloids and their semisynthetic derivatives.
ISSN:1420-3049
1420-3049