Don't be late! Timely identification of cognitive impairment in people with multiple sclerosis: a study protocol

Cognitive impairment occurs in up to 65% of people with multiple sclerosis (PwMS), negatively affecting daily functioning and health-related quality of life. In general, neuropsychological testing is not part of standard MS-care due to insufficient time and trained personnel. Consequently, a baselin...

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Published in:	BMC neurology 2024-01, Vol.24 (1), p.26-26, Article 26
Main Authors:	Waskowiak, Pauline T, de Jong, Brigit A, Uitdehaag, Bernard M J, Saddal, Shalina R D, Aarts, Jip, Roovers, Aïda A M, van Oirschot, Pim, de Groot, Vincent, Schaafsma, Frederieke G, van der Hiele, Karin, Ruitenberg, Marit F L, Schoonheim, Menno M, Widdershoven, Guy A M, van der Veen, Sabina, Schippers, Esther C F, Klein, Martin, Hulst, Hanneke E
Format:	Article
Language:	eng
Subjects:	Cognition Cognition disorders Cognitive Dysfunction - diagnosis Cognitive Dysfunction - etiology Cognitive impairment Complications and side effects Cross-Sectional Studies Diagnosis Digital screening Health-related quality of life Humans Innovation Mental health screening Methods Multicenter Studies as Topic Multiple sclerosis Multiple Sclerosis - complications Multiple Sclerosis - diagnosis Multiple Sclerosis - psychology Neuropsychological Tests Neuropsychology Quality of Life - psychology Reproducibility of Results Risk factors Technology application Testing
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Summary:	Cognitive impairment occurs in up to 65% of people with multiple sclerosis (PwMS), negatively affecting daily functioning and health-related quality of life. In general, neuropsychological testing is not part of standard MS-care due to insufficient time and trained personnel. Consequently, a baseline assessment of cognitive functioning is often lacking, hampering early identification of cognitive decline and change within a person over time. To assess cognitive functioning in PwMS in a time-efficient manner, a BICAMS-based self-explanatory digital screening tool called the Multiple Screener , has recently been developed. The aim of the current study is to validate the Multiple Screener in a representative sample of PwMS in the Netherlands. Additionally, we aim to investigate how cognitive functioning is related to psychological factors, and both work and societal participation. In this cross-sectional multicentre study, 750 PwMS (aged 18-67 years) are included. To obtain a representative sample, PwMS are recruited via 12 hospitals across the Netherlands. They undergo assessment with the Minimal Assessment of Cognitive Functioning in MS (MACFIMS; reference-standard) and the Multiple Screener . Sensitivity, specificity, and predictive values for identifying (mild) cognitive impairment are determined in a subset of 300 participants. In a second step, the identified cut-off values are tested in an independent subset of at least 150 PwMS. Moreover, test-retest reliability for the Multiple Screener is determined in 30 PwMS. Information on psychological and work-related factors is assessed with questionnaires. Validating the Multiple Screener in PwMS and investigating cognition and its determinants will further facilitate early identification and adequate monitoring of cognitive decline in PwMS.
ISSN:	1471-2377 1471-2377