Impact of the 23-valent pneumococcal polysaccharide vaccination in pregnancy against infant acute lower respiratory infections in the Northern Territory of Australia

Indigenous children in Australia's Northern Territory are densely colonised with the pneumococcus within weeks of birth antecedent to a high prevalence of acute lower respiratory infection (ALRI). We assessed the impact of the 23-valent pneumococcal polysaccharide vaccine (23vPPV) in pregnancy...

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Bibliographic Details
Published in:	Pneumonia 2018-12, Vol.10 (1), p.13-13, Article 13
Main Authors:	Binks, Michael J, Moberley, Sarah A, Balloch, Anne, Leach, Amanda J, Nelson, Sandra, Hare, Kim M, Wilson, Cate, Nelson, Jane, Morris, Peter S, Ware, Robert S, Tang, Mimi L K, Torzillo, Paul J, Carapetis, Jonathan R, Mulholland, Kim, Andrews, Ross M
Format:	Article
Language:	eng
Subjects:	23-valent pneumococcal polysaccharide vaccine Acute lower respiratory infection Age Australia Babies Ear diseases Hospitals Indigenous Infections Influenza Medical records Pneumonia Pregnancy Primary care Streptococcus infections Surveillance Vaccines
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Summary:	Indigenous children in Australia's Northern Territory are densely colonised with the pneumococcus within weeks of birth antecedent to a high prevalence of acute lower respiratory infection (ALRI). We assessed the impact of the 23-valent pneumococcal polysaccharide vaccine (23vPPV) in pregnancy against infant ALRI in this setting. In an open label, allocation concealed, outcome-assessor blinded, randomised controlled trial conducted in the Northern Territory of Australia, healthy Indigenous women aged 17-39 years were randomised to receive the 23vPPV during pregnancy ( = 75; 30-36 weeks gestation), at birth ( = 75), or at 7 months post-partum ( = 77). Randomisation was stratified by community of residence. In a secondary analysis, we compared the incidence of ALRI hospitalisations and ALRI clinic presentations (ascertained from electronic medical records) among infants of pregnancy vaccinees versus infants of mothers not vaccinated in pregnancy (controls) in the first year of life. ALRI hospitalisation incidence was 12.3 per 100 child-years among infants of pregnancy vaccinees compared with 15.8 per 100 child-years among controls (hazard ratio (HR) 0.77, 95%CI 0.29-2.03). ALRI hospitalisations were more common among remote compared to urban infants (27.7 versus 8.6 per 100 child-years). Stratification by dwelling highlighted a differential antenatal vaccine effect against ALRI hospitalisations ( HR 2.45, 95%CI 0.60-9.99; HR 0.21, 95%CI 0.04-1.08). ALRI clinic presentation incidence was similar among infants of pregnancy vaccinees and controls. In this small study, antenatal 23vPPV vaccination was not associated with a reduced incidence of infant ALRI hospitalisations or ALRI clinic presentations during the first year of life. A potential differential effect between urban and remote settings warrants further investigation. PneuMum; ClinicalTrials.gov NCT00714064.
ISSN:	2200-6133 2200-6133