Navigating the ERK1/2 MAPK Cascade

Navigating the ERK1/2 MAPK Cascade

The RAS-ERK pathway is a fundamental signaling cascade crucial for many biological processes including proliferation, cell cycle control, growth, and survival; common across all cell types. Notably, ERK1/2 are implicated in specific processes in a context-dependent manner as in stem cells and pancre...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2023-10, Vol.13 (10), p.1555
Main Authors: Martin-Vega, Ana, Cobb, Melanie H
Format: Article
Language:eng
Subjects:
Amino acids
Beta cells
Cancer
Cell cycle
Cell survival
ERK1/2
Extracellular signal-regulated kinase
Growth factors
Humans
inhibitors
Kinases
Localization
MAP kinase
MAP Kinase Signaling System
MAPKs
Medical innovations
Mutation
Neoplasms - metabolism
Plasma
Proteins
Review
Sarcoma
scaffold
Senescence
Signal Transduction - physiology
Stem cells
therapies
Tumorigenesis
Tumors
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Summary:The RAS-ERK pathway is a fundamental signaling cascade crucial for many biological processes including proliferation, cell cycle control, growth, and survival; common across all cell types. Notably, ERK1/2 are implicated in specific processes in a context-dependent manner as in stem cells and pancreatic β-cells. Alterations in the different components of this cascade result in dysregulation of the effector kinases ERK1/2 which communicate with hundreds of substrates. Aberrant activation of the pathway contributes to a range of disorders, including cancer. This review provides an overview of the structure, activation, regulation, and mutational frequency of the different tiers of the cascade; with a particular focus on ERK1/2. We highlight the importance of scaffold proteins that contribute to kinase localization and coordinate interaction dynamics of the kinases with substrates, activators, and inhibitors. Additionally, we explore innovative therapeutic approaches emphasizing promising avenues in this field.
ISSN:2218-273X
2218-273X