Long‐standing laryngeal rhinoscleroma with rare Mikulicz cells

Key Clinical Message Rhinoscleroma is an infectious granulomatous disease. It is important to identify pathognomonic Mikulicz cells on microscopy, as these can be rare and the chronic inflammatory infiltrate can appear otherwise nonspecific on biopsies. Top left. Direct laryngoscopic image of suprag...

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Bibliographic Details
Published in:	Clinical case reports 2023-06, Vol.11 (6), p.e7490-n/a
Main Authors:	Peerani, Raheem, Shah, Manish, Minnema, Brian, Ghaffar, Hasan, Chetty, Runjan, Delabie, Jan, Perez‐Ordonez, Bayardo, Xia, Daniel
Format:	Article
Language:	eng
Subjects:	Biopsy Case Image Case Images Conflicts of interest Consent ear Editing Haematology infectious disease Klebsiella ozaenae Larynx Mikulicz cells nose and throat Ostomy rhinoscleroma Tracheotomy Writing
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Summary:	Key Clinical Message Rhinoscleroma is an infectious granulomatous disease. It is important to identify pathognomonic Mikulicz cells on microscopy, as these can be rare and the chronic inflammatory infiltrate can appear otherwise nonspecific on biopsies. Top left. Direct laryngoscopic image of supraglottic larynx showing an irregular ulcerative mass. Top right. Axial CT images taken after the patient's tracheostomy was completed. There is a mass visible in the supraglottic larynx (green arrows) that is causing narrowing of the airway. Emphysematous changes in the soft tissue are the result of the surgical procedure. Nasogastric tube can be seen in the esophagus. Bottom. On microscopy, H&E (left) and Gram (right) stains show rare Mikulicz cells (black arrows), which are histiocytes that contain intracellular bacteria (gram‐negative rods on the Gram stain), in a background of numerous lymphocytes and plasma cells.
ISSN:	2050-0904 2050-0904