The role of PI3K/Akt signalling pathway in spinal cord injury

Spinal cord injury (SCI) is a severely disabling central nervous system injury with complex pathological mechanisms that leads to sensory and motor dysfunction. The current treatment for SCI is aimed at symptomatic symptom relief rather than the pathological causes. Several studies have reported tha...

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Bibliographic Details
Published in:	Biomedicine & pharmacotherapy 2022-12, Vol.156, p.113881-113881, Article 113881
Main Authors:	Xiao, Chun-Lin, Yin, Wen-Chao, Zhong, Yan-Chun, Luo, Jia-Quan, Liu, Lu-Lin, Liu, Wu-Yang, Zhao, Kai
Format:	Article
Language:	eng
Subjects:	Akt Mechanism PI3K Spinal cord injury (SCI) Therapeutic target
Online Access:	Get full text
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Summary:	Spinal cord injury (SCI) is a severely disabling central nervous system injury with complex pathological mechanisms that leads to sensory and motor dysfunction. The current treatment for SCI is aimed at symptomatic symptom relief rather than the pathological causes. Several studies have reported that signaling pathways play a key role in SCI pathological processes and neuronal recovery mechanisms. The PI3K/Akt signaling pathway is an important pathway closely related to the pathological process of SCI, and activation of this pathway can delay the inflammatory response, prevent glial scar formation, and promote neurological function recovery. Activation of this pathway can promote the recovery of neurological function after SCI by reducing cell apoptosis. Based on the role of the PI3K/Akt pathway in SCI, it may be a potential therapeutic target. This review highlights the role of activating or inhibiting the PI3K/Akt signaling pathway in SCI-induced inflammatory response, apoptosis, autophagy, and glial scar formation. We also summarize the latest evidence on treating SCI by targeting the PI3K/Akt pathway, discuss the shortcomings and deficiencies of PI3K/Akt research in the field of SCI, and identify potential challenges in developing these clinical therapeutic SCI strategies, and provide appropriate solutions. •This paper reviews the recent literature on PI3K/Akt signaling pathway and spinal cord injury.•According to the role of PI3K/Akt pathway in spinal cord injury, the role of PI3K/Akt pathway on SCI field was summarized.•It is concluded that PI3K/Akt pathway may be a potential therapeutic target for spinal cord injury.
ISSN:	0753-3322 1950-6007