Abnormal brain white matter in patients with right trigeminal neuralgia: a diffusion tensor imaging study

Background Idiopathic or classical trigeminal neuralgia (TN) is a chronic painful condition characterized by intermittent pain attacks. Enough evidence demonstrates classical TN is related to neurovascular compression (NVC) at the trigeminal root entry zone (REZ), but white matter change secondary t...

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Bibliographic Details
Published in:	Journal of headache and pain 2018-06, Vol.19 (1), p.46-8, Article 46
Main Authors:	Liu, Junpeng, Zhu, Jiajia, Yuan, Fei, Zhang, Xuejun, Zhang, Quan
Format:	Article
Language:	eng
Subjects:	Adult Aged Attention Deficit Hyperactivity Disorder Brain - diagnostic imaging Compression Corpus callosum Diffusion Tensor Imaging - methods Female Fornix Humans Internal Medicine Magnetic resonance imaging Male Medicine Medicine & Public Health Middle Aged Neuralgia Neuroimaging Neurology Neurovascular compression Pain Pain Medicine Research Article Statistical analysis Substantia alba Tract-based spatial statistics Trigeminal neuralgia Trigeminal Neuralgia - diagnostic imaging White matter White Matter - diagnostic imaging
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Summary:	Background Idiopathic or classical trigeminal neuralgia (TN) is a chronic painful condition characterized by intermittent pain attacks. Enough evidence demonstrates classical TN is related to neurovascular compression (NVC) at the trigeminal root entry zone (REZ), but white matter change secondary to TN are not totally known. Methods Visual Analogue Scale (VAS) and diffusion tensor imaging were performed on 29 patients with right TN and 35 healthy individuals. Voxel-wise analyses were performed with TBSS using multiple diffusion metrics, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD). Group differences in these parameters were compared between right TN patients and controls using TBSS and correlations between the white matter change and disease duration and VAS in right TN patients were assessed. Multiple comparison correction were applied to test significant correlations. Results The right TN patients showed significantly lower FA and higher RD in most left white matter ( P
ISSN:	1129-2369 1129-2377