The Treatment of Impaired Wound Healing in Diabetes: Looking among Old Drugs

The Treatment of Impaired Wound Healing in Diabetes: Looking among Old Drugs

Chronic wounds often occur in patients with diabetes mellitus due to the impairment of wound healing. This has negative consequences for both the patient and the medical system and considering the growing prevalence of diabetes, it will be a significant medical, social, and economic burden in the ne...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2020-04, Vol.13 (4), p.60
Main Authors: Spampinato, Simona Federica, Caruso, Grazia Ilaria, De Pasquale, Rocco, Sortino, Maria Angela, Merlo, Sara
Format: Article
Language:eng
Subjects:
Angiogenesis
Cytokines
Diabetes
diabetic foot ulcer
DPP4 inhibitor
Extracellular matrix
Fibroblasts
Foot diseases
Hyperglycemia
Hypoxia
metformin
Neutrophils
phenytoin
Recruitment
Review
Skin
statins
Ulcers
Vascular endothelial growth factor
wound closure
Wound healing
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chronic wounds often occur in patients with diabetes mellitus due to the impairment of wound healing. This has negative consequences for both the patient and the medical system and considering the growing prevalence of diabetes, it will be a significant medical, social, and economic burden in the near future. Hence, the need for therapeutic alternatives to the current available treatments that, although various, do not guarantee a rapid and definite reparative process, appears necessary. We here analyzed current treatments for wound healing, but mainly focused the attention on few classes of drugs that are already in the market with different indications, but that have shown in preclinical and few clinical trials the potentiality to be used in the treatment of impaired wound healing. In particular, repurposing of the antiglycemic agents dipeptidylpeptidase 4 (DPP4) inhibitors and metformin, but also, statins and phenyotin have been analyzed. All show encouraging results in the treatment of chronic wounds, but additional, well designed studies are needed to allow these drugs access to the clinics in the therapy of impaired wound healing.
ISSN:1424-8247
1424-8247