Heiner Syndrome and Milk Hypersensitivity: An Updated Overview on the Current Evidence

Infants affected by Heiner syndrome (HS) display chronic upper or lower respiratory tract infections, including otitis media or pneumonia. Clinically, gastrointestinal signs and symptoms, anemia, recurrent fever and failure to thrive can be also present. Chest X-rays can show patchy infiltrates mimi...

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Bibliographic Details
Published in:	Nutrients 2021-05, Vol.13 (5), p.1710
Main Authors:	Arasi, Stefania, Mastrorilli, Carla, Pecoraro, Luca, Giovannini, Mattia, Mori, Francesca, Barni, Simona, Caminiti, Lucia, Castagnoli, Riccardo, Liotti, Lucia, Saretta, Francesca, Marseglia, Gian Luigi, Novembre, Elio
Format:	Article
Language:	eng
Subjects:	allergy Anemia Antigen-antibody complexes Biopsy children cow’s milk Diet Enteral nutrition Fever Health aspects Histamine Hypersensitivity Immunology Iron Laboratories Lung diseases Milk Milk free non-IgE-mediated food allergy Nutrition research Otitis media Patients Plant-based beverages Pneumonia Proteins Respiratory diseases Respiratory tract Respiratory tract diseases Review Signs and symptoms
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Summary:	Infants affected by Heiner syndrome (HS) display chronic upper or lower respiratory tract infections, including otitis media or pneumonia. Clinically, gastrointestinal signs and symptoms, anemia, recurrent fever and failure to thrive can be also present. Chest X-rays can show patchy infiltrates miming pneumonia. Clinical manifestations usually disappear after a milk-free diet. The pathogenetic mechanism underlying HS remains unexplained, but the formation of immune complexes and the cell-mediated reaction have been proposed. Patients usually outgrow this hypersensitivity within a few years. The aim of this review is to provide an updated overview on the current evidence on HS in children, with a critical approach on the still undefined points of this interesting disease. Finally, we propose the first structured diagnostic approach for HS.
ISSN:	2072-6643 2072-6643