Challenges in stem cell-derived islet replacement therapy can be overcome

In this Commentary, we echo the conclusions of a recent review titled “The promise of stem cell-derived islet replacement therapy,” which highlighted recent advances in producing glucose responsive “islets” from stem cells and the benefits of their use in islet transplant therapy in type 1 diabetes...

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Bibliographic Details
Published in:	Cell transplantation 2021, Vol.30, p.96368972110453-9636897211045320
Main Authors:	Abdulreda, Midhat H., Berggren, Per-Olof
Format:	Article
Language:	eng
Subjects:	Allografts Anterior chamber Diabetes mellitus (insulin dependent) Islet cells Medicin och hälsovetenskap Pancreas Pancreatic islet transplantation Reviews Stem cells Syngeneic grafts Transplants & implants
Online Access:	Get full text
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Summary:	In this Commentary, we echo the conclusions of a recent review titled “The promise of stem cell-derived islet replacement therapy,” which highlighted recent advances in producing glucose responsive “islets” from stem cells and the benefits of their use in islet transplant therapy in type 1 diabetes (T1D). The review also outlined the status of clinical islet transplantation and the challenges that have prevented it from reaching its full therapeutic promise. We agree with the conclusions of the review and suggest that the identified challenges may be overcome by using the eye anterior chamber as an islet transplant site. We anticipate that the combination of stem cell-derived islets and intraocular transplant could help this promising T1D therapy reach full fruition.
ISSN:	0963-6897 1555-3892 1555-3892