The seahorse ( Hippocampus comes L.) extract ameliorates sperm qualities, testosterone level, and serum biochemistry in rats induced by depo medroxyprogesterone acetate

The percentage of infertility cases in this world is about 50%. Seahorses ( spp.) are widely used in traditional medicine. Several studies suggest that seahorses have ethnopharmacological characteristics, such as fertility, antioxidants, and antifatigue. The purpose of this study was to determine wh...

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Bibliographic Details
Published in:Journal of advanced veterinary and animal research 2023-03, Vol.10 (1), p.126-131
Main Authors: Mundijo, Trisnawati, Suyatna, Franciscus Dhyanagiri, Wibowo, Agung Eru, Lestari, Silvia Werdhy, Yusra, Yusra, Midoen, Yurnadi Hanafi
Format: Article
Language:English
Subjects:
Acetic acid
Animals
Biochemistry
Cholesterol
dmpa
seahorse
serum biochemistry
spermatozoa
testosterone
Drug dosages
Endocrine system
Fertility
High density lipoprotein
Hippocampus comes
Hippocampus hippocampus
Infertility
Medicine
Medroxyprogesterone acetate
Motility
Original
Semen
Sperm
Spermatogenesis
Spermatozoa
Testosterone
Variance analysis
Vas deferens
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Summary:The percentage of infertility cases in this world is about 50%. Seahorses ( spp.) are widely used in traditional medicine. Several studies suggest that seahorses have ethnopharmacological characteristics, such as fertility, antioxidants, and antifatigue. The purpose of this study was to determine whether seahorse extract (SE) ( L.) has an effect on fertility and serum biochemistry in rats induced by depo medroxyprogesterone acetate (DMPA). All animals were induced with 1.25 mg/kg BW of DMPA. Animals were grouped into five groups: namely aquadest, 1% CMC, and SE doses of 150, 225, and 300 mg/kg BW. The rats were gavage every morning from week 7 until 18. At the end of our study, semen from the vas deferens and blood from the heart were analyzed. We analyzed with a one-way analysis of variance and Bonferroni's post hoc tests (α 95%). The concentration of spermatozoa had a significant difference in dose of 150 mg/kg BW compared to other groups ( 0.04). In contrast, the motility ( = 0.012) and viability of spermatozoa ( 0.007) were highly significant differences ( 0.05 and 0.01) at 300 mg/kg BW. Testosterone levels were not significantly ( = 0.162; > 0.05), but tended to increase at 300 mg/kg BW (11.01%). Nevertheless, serum biochemistry was insignificant ( 0.05) in all groups. SE ( L.) ameliorates fertility and serum biochemistry in rats induced by DMPA.
ISSN:2311-7710
2311-7710
DOI:10.5455/javar.2023.j661