Low periostin expression predicts poor survival in intestinal type gastric cancer patients

Periostin is a protein from the Fascilin family. It is commonly present in normal tissues and is responsible for cell adhesion. Evidence has emerged showing that changes in periostin expression play an important role in tumor initiation, development, and progression. This study aims to investigate t...

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Bibliographic Details
Published in:	Cancer management and research 2019-01, Vol.11, p.25-36
Main Authors:	Zhang, Teming, Han, Zheng, Chandoo, Arvine, Huang, Xincheng, Sun, Xiangwei, Ye, Lele, Hu, Changyuan, Xue, Xiangyang, Huang, Yingpeng, Shen, Xian, Chang, Wenjun, Lin, Xiaoming
Format:	Article
Language:	eng
Subjects:	Antigens Cancer Cancer patients Cell adhesion & migration Chemotherapy Classification Development and progression Gastric cancer Gene expression Hospitals Immunohistochemistry Immunology Kinases Lymph Node Metastasis Lymphatic system Metastasis Oncology, Experimental Original Research Patient outcomes Periostin expression Prognosis Proteins RNA Stomach cancer Studies Surgery Thoracic surgery Tissue microarray Tumor microenvironment Tumors
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Summary:	Periostin is a protein from the Fascilin family. It is commonly present in normal tissues and is responsible for cell adhesion. Evidence has emerged showing that changes in periostin expression play an important role in tumor initiation, development, and progression. This study aims to investigate the effect of periostin in gastric cancer (GC) patients who underwent gastrectomy. Seven hundred and forty-seven GC patients who underwent gastrectomy between December 2006 and July 2011 were included in this study. Seven hundred and forty-seven cancer tissues and 70 paired adjacent normal tissues were collected. Periostin expression was evaluated by immunohistochemistry. The Gene Expression Omnibus database was used to study the association between the mRNA level and patient's overall survival. The tumor microenvironment was also studied. Periostin expression in stroma was downregulated in tumor tissues but it was upregulated in the epithelial cells. After dividing the tissues according to the Lauren Classification, we found that periostin expression in stroma and epithelial cells was higher in intestinal type than in diffuse type (
ISSN:	1179-1322 1179-1322