Nanoparticle elasticity directs tumor uptake

To date, the role of elasticity in drug delivery remains elusive due to the inability to measure microscale mechanics and alter rheology without affecting chemistry. Herein, we describe the in vitro cellular uptake and in vivo tumor uptake of nanolipogels (NLGs). NLGs are composed of identical lipid...

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Bibliographic Details

Published in:	Nature communications 2018-01, Vol.9 (1), p.130-130, Article 130
Main Authors:	Guo, Peng, Liu, Daxing, Subramanyam, Kriti, Wang, Biran, Yang, Jiang, Huang, Jing, Auguste, Debra T, Moses, Marsha A
Format:	Article
Language:	eng
Subjects:	Alginic acid Animals Atomic force microscopy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line Cell Line, Tumor Chlorpromazine - pharmacology Design parameters Drug delivery Drug delivery systems Elastic Modulus Elasticity Endocytosis - drug effects Filipin - pharmacology Humans Hydrazones - pharmacology Lipid bilayers Liver Liver - metabolism Mammary Neoplasms, Experimental - metabolism MCF-7 Cells Mechanical properties Mice, Inbred BALB C Microscopy Microscopy, Atomic Force Modulus of elasticity Nanoparticles Nanoparticles - chemistry Nanoparticles - metabolism Rheological properties Rheology Tumors
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