An Efficient Synthesis of Novel Bioactive Thiazolyl-Phthalazinediones under Ultrasound Irradiation

Novel 2-thiazolylphthalazine derivatives were efficiently synthesized under ultrasound irradiation, resulting in high yields and short reaction times after optimization of the reaction conditions. All prepared compounds were fully characterized using spectroscopic methods. They were screened for the...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2017-02, Vol.22 (2), p.319-319
Main Authors: Elsharabasy, Fatma S, Gomha, Sobhi M, Farghaly, Thoraya A, Elzahabi, Heba S A
Format: Article
Language:English
Subjects:
Anti-Infective Agents - chemical synthesis
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Antifungal activity
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
Bacteria
Bacteria - drug effects
Chemistry Techniques, Synthetic
Fungi
Fungi - drug effects
Fungicides
Gentamicin
Gram-negative bacteria
Gram-positive bacteria
hydrazonoyl chlorides
Inhibition
Irradiation
Molecular Structure
Optimization
Phthalazines - chemical synthesis
Phthalazines - chemistry
Phthalazines - pharmacology
Radiation
Salmonella
Structure-Activity Relationship
Thiazoles - chemistry
thiazolylphthalazinediones
Ultrasonic imaging
Ultrasonic Waves
Ultrasound
ultrasound irradiation
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Summary:Novel 2-thiazolylphthalazine derivatives were efficiently synthesized under ultrasound irradiation, resulting in high yields and short reaction times after optimization of the reaction conditions. All prepared compounds were fully characterized using spectroscopic methods. They were screened for their antimicrobial activity against Gram-positive and Gram-negative bacteria as well as for antifungal activity. The antimicrobial activity profile of the tested compounds showed some promising results. The potent activity of compounds , (117% zone inhibition) and (105% zone inhibition) against , exceeding that of the reference drug is particularly noteworthy. In general, the newly synthesized thiazolylphthalazine derivatives showed higher antimicrobial activity against the tested Gram-negative bacteria than against Gram-positive bacteria and fungi.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules22020319