Circulating MicroRNAs in Cancer: Potential and Challenge

Circulating MicroRNAs in Cancer: Potential and Challenge

MicroRNAs (miRNAs) are endogenous non-coding small RNA molecules that can be secreted into the circulation and exist in remarkably stable forms. Like intercellular miRNAs, circulating miRNAs participate in numerous regulations of biological process and expressed aberrantly under abnormal or patholog...

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Bibliographic Details
Published in:Frontiers in genetics 2019-07, Vol.10, p.626-626
Main Authors: Cui, Mengying, Wang, Hongdan, Yao, Xiaoxiao, Zhang, Dan, Xie, Yingjun, Cui, Ranji, Zhang, Xuewen
Format: Article
Language:eng
Subjects:
biomarker
cancer
circulating
communication
Genetics
miRNAs
therapy
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Summary:MicroRNAs (miRNAs) are endogenous non-coding small RNA molecules that can be secreted into the circulation and exist in remarkably stable forms. Like intercellular miRNAs, circulating miRNAs participate in numerous regulations of biological process and expressed aberrantly under abnormal or pathological status. The quality and quantity changes of circulating miRNAs are associated with the initiation and progression of cancer and can be easily detected by basic molecular biology techniques. Consequently, considerable effort has been devoted to identify suitable extracellular miRNAs for noninvasive biomarkers in cancer. However, several challenges need to be overcome before the practical application. In this review, we discuss several issues of circulating miRNAs: biological function and basic transport carriers; extracellular cell communication process; roles as reliable cancer biomarkers and usage in targeted cancer therapy; and challenges for clinical application.
ISSN:1664-8021
1664-8021