Spinal apolipoprotein E is involved in inflammatory pain via regulating lipid metabolism and glial activation in the spinal dorsal horn

Inflammation and nerve injury promote astrocyte activation, which regulates the development and resolution of pain, in the spinal dorsal horn. APOE regulates lipid metabolism and is predominantly expressed in the astrocytes. However, the effect of astrocytic APOE and lipid metabolism on spinal cellu...

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Bibliographic Details

Published in:	Biology direct 2023-12, Vol.18 (1), p.85-85, Article 85
Main Authors:	Liu, Siyi, Yang, Shuting, Zhu, Xuan, Li, Xiang, Zhang, Xi, Zhou, Xiaoqiong, Cheng, Hong, Huo, Fu-Quan, Mao, Qingxiang, Liang, Lingli
Format:	Article
Language:	eng
Subjects:	Animals Antisense oligonucleotides Apolipoprotein E Apolipoproteins Apolipoproteins E - genetics Apolipoproteins E - metabolism Astrocyte Astrocytes Care and treatment Chronic pain Complete Freund's adjuvant Diagnosis DNA-directed RNA polymerase Dorsal horn Edema Excitability Freund's adjuvant Freund's Adjuvant - adverse effects Gene sequencing Health aspects Homeostasis Hyperalgesia - chemically induced Hyperalgesia - genetics Hyperalgesia - metabolism Hypersensitivity Immune response Immune system Immunofluorescence Inflammation Inflammatory pain Injection Life sciences Lipid Metabolism Lipids Metabolism Mice Mice, Knockout, ApoE Nervous system Neurons Pain Pain - chemically induced Pain - metabolism Pain perception Physiology Polymerase chain reaction Spinal cord Spinal Cord Dorsal Horn - metabolism Spinal diseases Spinal dorsal horn Transcriptomics Western blotting
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